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Table 3 Antifungal susceptibility profile of 320 oral yeast isolates from HIV-infected patients from Kunming, China

From: Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan Province of China

Species (No.) Antifungal agent MIC range (μg/mL) No. of S strains (%)a No. of S-DD strains (%)b No. of R strains (%)c
C. albicans (263) Fluconazole 0.125-64 251 (95.0) 3 (1.1) 9 (3.4)
  Itraconazole 0.031-16 232 (88.2) 13 (4.9) 18 (6.8)
  Voriconazole 0.031-16 255 (97.0) - 8 (3.0)
  Amphotericin B 0.125-1 263 (100.0) - 0 (0)
C. glabrata (29) Fluconazole 0.25-64 23 (79.3) 1 (3.4) 5 (17.2)
  Itraconazole 0.031-16 7 (24.1) 7 (24.1) 15 (51.7)
  Voriconazole 0.031-16 25 (86.2) - 4 (13.8)
  Amphotericin B 0.25-1 29 (100.0) - 0 (0)
C. krusei (10) Fluconazole 8-64 3 (30.0) 5 (50.0) 2 (20.0)
  Itraconazole 0.125-4 1 (10.0) 3 (30.0) 6 (60.0)
  Voriconazole 0.063-2 8 (80.0) - 2 (20.0)
  Amphotericin B 0.25-1 10 (100.0) - 0 (0)
C. tropicalis (2) Fluconazole 64 0 (0) 0 (0) 2 (100)
  Itraconazole 16 0 (0) 0 (0) 2 (100)
  Voriconazole 16 0 (0) - 2 (100)
  Amphotericin B 0.5-1 2 (100.0) - 0 (0)
C. parapsilosis (12) Fluconazole 0.125-1 12 (100.0) 0 (0) 0 (0)
  Itraconazole 0.031-2 6 (50.0) 4 (33.3) 2 (16.7)
  Voriconazole 0.031 12 (100.0) - 0 (0)
  Amphotericin B 0.25-1 12 (100.0) - 0 (0)
C. rugosa (1) Fluconazole 1 1 (100.0) 0 (0) 0 (0)
  Itraconazole 0.031 1 (100.0) 0 (0) 0 (0)
  Voriconazole 0.031 1 (100.0) - 0 (0)
  Amphotericin B 0.5 1 (100.0) - 0 (0)
C. norvegensis (1) Fluconazole 1 1 (100.0) 0 (0) 0 (0)
  Itraconazole 0.25 1 (100.0) 0 (0) 0 (0)
  Voriconazole 0.063 1 (100.0) - 0 (0)
  Amphotericin B 1 1 (100.0) - 0 (0)
Pichia ohmeri (1) Fluconazole 8 1 (100.0) 0 (0) 0 (0)
  Itraconazole 2 0 (0) 0 (0) 1 (100)
  Voriconazole 0.125 1 (100.0) - 0 (0)
  Amphotericin B 0.5 1 (100.0) - 0 (0)
Saccharomyces cerevisiae (1) Fluconazole 16 0 (0) 1 (100.0) 0 (0)
  Itraconazole 0.25 0 (0) 1 (100.0) 0 (0)
  Voriconazole 0.125 1 (100.0) - 0 (0)
  Amphotericin B 1 1 (100.0) - 0 (0)
  1. a Susceptible (S) strains were defined by MIC ≤8 μg/mL for fluconazole, ≤0.125 μg/mL for itraconazole, <1 μg/mL for voriconazole and ≤ 1 μg/mL for amphotericin B.
  2. b Susceptible-dose dependent (S-DD) strains were defined by MICs between 16 μg/mL and 32 μg/mL for fluconazole and between 0.25 μg/mL and 0.5 μg/mL for itraconazole.
  3. c Resistant (R) strains were defined by MIC ≥64 μg/mL for fluconazole, ≥1 μg/mL for itraconazole and voriconazole, and >1 μg/mL for amphotericin B.
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BMC Infectious Diseases

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