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Table 2 Minimum inhibitory concentration (MIC) for second-line drugs (N = 22 isolates)

From: Application of quantitative second-line drug susceptibility testing at a multidrug-resistant tuberculosis hospital in Tanzania

Drug

Susceptible (% N)

Borderline susceptible (% N)

Resistant (% N)

[MIC range]

[MIC range]

[MIC range]

Kanamycin

11 (50)

10 (45)

1 (5)

[≤0.6-1.2 μg/ml]

[2.5-5.0 μg/ml]

[>40.0 μg/ml]

Amikacin

15 (68)

6 (27)

1 (5)

[≤0.12-0.25 μg/ml]

[≤0.5-1.0 μg/ml]

[16 μg/ml]

Ofloxacina

12 (55)

10 (45)

0

[≤0.25-0.5 μg/ml]

[1.0-2.0 μg/ml]

N/A

Moxifloxacin

11 (50)

10 (45)

1 (5)

[≤0.6 μg/ml]

[≤0.12-0.25 μg/ml]

[0.5 μg/ml]

Ethionamide

11 (50)

8 (36)

3 (14)

[0.5-1.2 μg/ml]

[2.5-5.0 μg/ml]

[10.0-40.0 μg/ml]

Cycloserine

17 (77)

5 (23)

0

[1.2-8.0 μg/ml]

[16.0-32.0 μg/ml]

N/A

PAS

15 (68)

2 (9)

5 (23)

[≤0.5 μg/ml]

[1.0 μg/ml]

[8.0- >64.0 μg/ml]

Rifabutin

9 (41)

0

13 (59)

[≤0.12 μg/ml]

N/A

[1.0- >16.0 μg/ml]

  1. PAS para-aminosalicylic acid. aPatients received ofloxacin or levofloxacin. Moxifloxacin and rifabutin were not available on formularly.