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Table 2 Association of HIV/HCV group with concurrently elevated (>75th percentile) inflammatory biomarkers

From: Human immunodeficiency virus, hepatitis C, and inflammatory biomarkers in individuals with alcohol problems: a cross-sectional study

Model A (N = 218) Unadjusted Adjusteda
  POR(95% CI) p-value POR(95% CI) p-value
Undetectable 1 -- 1 --
  HIV mono-detectable 1.89 (1.03, 3.46) 0.04 1.52 (0.68, 3.41) 0.31
  HCV mono-detectable 2.70 (1.29, 5.68) <0.01 2.95 (1.08, 8.01) 0.03
  HIV/HCV detectable 3.48 (1.87, 6.46) <0.01 2.49 (1.05, 5.89) 0.04
FIB-4 ≥ 1.45 -- -- 2.56 (1.39, 4.35) <0.01
High cholesterol -- -- 1.74 (0.97, 3.14) 0.06
Age greater than median (42 yrs) -- -- 0.61 (0.36, 1.04) 0.07
BMI ≥ 30 kg/m2 -- -- 1.81 (0.93, 3.54) 0.08
Ever smoker -- -- 1.53 (0.85, 2.78) 0.16
CD4 > 200 cells/mm3 -- -- 0.63 (0.31, 1.26) 0.19
Renal disease -- -- 2.15 (0.67, 6.86) 0.20
Diabetes -- -- 1.90 (0.58, 6.21) 0.29
Current antiretroviral therapy use -- -- 0.74 (0.42, 1.31) 0.30
Prevalent cardiovascular disease -- -- 1.82 (0.56, 5.97) 0.32
Hypertension -- -- 0.78 (0.42, 1.45) 0.44
At-risk alcohol consumption -- -- 0.94 (0.55, 1.62) 0.83
Female -- -- 1.03 (0.55, 1.94) 0.93
  1. aModel adjusted for age, gender, FIB-4 score, at-risk drinking, CD4 count, ART use, and self-reported comorbidity.
  2. The ordinal logistic regression model estimates the proportional odds of having more than N concurrently elevated biomarkers versus N or fewer where N = 0, 1, 2, or 3 or more.
  3. P OR proportional odds ratio, HIV human immunodeficiency virus, HCV hepatitis C virus, FIB 4-liver fibrosis index-4, BMI body mass index, CD4-CD4+ T-lymphocyte count.
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