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Table 1 Identification of differentially expressed proteins of extremely severe HFMD patients by MALDI-TOF/TOF

From: Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71

Spot no* Protein name Accession NO. Protein MW(kDa) Protein pI Protein score C.1.% Ratio (S/N)
1 Ceruloplasmin P00450 122.98 5.44 99.96 -2.31
2 Ceruloplasmin E9PFZ2 109.49 5.49 100 -3.006
3 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 F5H194 98.55 6.21 100 -3.574
4 Inter-alpha-trypsin inhibitor heavy chain H2 P19823 106.85 6.4 100 -1.889
5 Serum albumin E7ESU5 72.46 5.82 100 -3.598
6 Serum albumin (Fragment) H0YA55 53.08 6.45 100 -5.505
7 Serum albumin (Fragment) H0YA55 53.08 6.45 100 -3.019
8 C2ORF3 variant 2 A4UHQ9 28.03 5.08 96.214 1.887
9 Plasminogen P00747 93.25 7.04 99.995 -2.122
10 Plasminogen P00747 93.25 7.04 100 -2.81
11 Plasminogen P00747 93.25 7.04 99.987 -2.981
12 Alpha-2-macroglobulin P01023 164.61 6.03 100 -1.5799
13 Pigment epithelium-derived factor P36955 46.45 5.97 96.992 1.621
14 Hemopexin P02790 52.38 6.55 100 -1.566
15 Ig alpha-2 chain C region P01877 37.30 5.71 100 1000000
16 Cdna FLJ55673 highly similar to complement fator B B4E1Z4 143.19 6.82 99.862 5.1141
17 Complement C3 P01024 188.57 6.02 99.63 -7.118
18 Clusterin alpha chain (Fragment) H0YAS8 16.22 5.51 100 5.212
19 Haptoglobin beta chain I3L0D3 31.67 8.48 100 1.612
20 Haptoglobin beta chain I3L0D3 31.67 8.48 100 1.845
21 Haptoglobin beta chain I3L0D3 31.67 8.48 100 1.8315
22 MTHFSD Uncharacterized B7ZLC2 24.26 6.97 95.54 2.6638
23 Haptoglobin beta chain I3L0D3 31.67 8.48 100 3.569
24 Isoform 1 of Ficolin-3 O75636 33.40 6.20 100 1.8743
25 Isoform 2 of Ficolin-3 O75636 32.11 6.36 100 1.9465
26 Apolipoprotein L1 E9PF24 42.19 5.58 96.777 1000000
27 complement component 4B preproprotein B4E344 194.17 6.89 99.987 2.1058
28 DADB-112B14.11 Complement component 4B B0UZ85 194.17 6.89 100 2.404
29 IGK@ protein Q6P5S8 26.04 5.94 99.398 2.004
30 Peroxiredoxin-2 P32119 22.05 5.66 100 9.686
31 Ig kappa chain V-III region WOL P01623 11.85 9.07 100 2.489
32 Keratin, type II cytoskeletal 1 P04264 66.17 8.15 99.112 2.4587
33 Keratin, type II cytoskeletal 6C P48668 60.27 8.09 100 2.5654
34 Apolipoprotein A-1 P02647 30.76 5.56 100 4.3662
35 Serum amyloid P-component P02743 25.49 6.10 100 3.863
36 Retinol-binding protein 4 P02753 23.34 5.76 100 -2.876
37 Haptoglobin beta chain H0Y300 22.53 5.96 97.871 1.527
38 HPR 47 kDa protein P00738 47.38 6.28 100 1.7345
  1. “1000000”—only appeared in the extremely severe HFMD patients, but not appeared in the healthy children.
  2. *Spot numbers correspond to the numbers marked in Figure 1.
  3. Note: some proteins showed in the 2-DE as multiple spots, probably due to their isoforms and/or modifications.