Table 1 Identification of differentially expressed proteins of extremely severe HFMD patients by MALDI-TOF/TOF
From: Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71
Spot no* | Protein name | Accession NO. | Protein MW(kDa) | Protein pI | Protein score C.1.% | Ratio (S/N) |
|---|---|---|---|---|---|---|
1 | Ceruloplasmin | P00450 | 122.98 | 5.44 | 99.96 | -2.31 |
2 | Ceruloplasmin | E9PFZ2 | 109.49 | 5.49 | 100 | -3.006 |
3 | 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 | F5H194 | 98.55 | 6.21 | 100 | -3.574 |
4 | Inter-alpha-trypsin inhibitor heavy chain H2 | P19823 | 106.85 | 6.4 | 100 | -1.889 |
5 | Serum albumin | E7ESU5 | 72.46 | 5.82 | 100 | -3.598 |
6 | Serum albumin (Fragment) | H0YA55 | 53.08 | 6.45 | 100 | -5.505 |
7 | Serum albumin (Fragment) | H0YA55 | 53.08 | 6.45 | 100 | -3.019 |
8 | C2ORF3 variant 2 | A4UHQ9 | 28.03 | 5.08 | 96.214 | 1.887 |
9 | Plasminogen | P00747 | 93.25 | 7.04 | 99.995 | -2.122 |
10 | Plasminogen | P00747 | 93.25 | 7.04 | 100 | -2.81 |
11 | Plasminogen | P00747 | 93.25 | 7.04 | 99.987 | -2.981 |
12 | Alpha-2-macroglobulin | P01023 | 164.61 | 6.03 | 100 | -1.5799 |
13 | Pigment epithelium-derived factor | P36955 | 46.45 | 5.97 | 96.992 | 1.621 |
14 | Hemopexin | P02790 | 52.38 | 6.55 | 100 | -1.566 |
15 | Ig alpha-2 chain C region | P01877 | 37.30 | 5.71 | 100 | 1000000 |
16 | Cdna FLJ55673 highly similar to complement fator B | B4E1Z4 | 143.19 | 6.82 | 99.862 | 5.1141 |
17 | Complement C3 | P01024 | 188.57 | 6.02 | 99.63 | -7.118 |
18 | Clusterin alpha chain (Fragment) | H0YAS8 | 16.22 | 5.51 | 100 | 5.212 |
19 | Haptoglobin beta chain | I3L0D3 | 31.67 | 8.48 | 100 | 1.612 |
20 | Haptoglobin beta chain | I3L0D3 | 31.67 | 8.48 | 100 | 1.845 |
21 | Haptoglobin beta chain | I3L0D3 | 31.67 | 8.48 | 100 | 1.8315 |
22 | MTHFSD Uncharacterized | B7ZLC2 | 24.26 | 6.97 | 95.54 | 2.6638 |
23 | Haptoglobin beta chain | I3L0D3 | 31.67 | 8.48 | 100 | 3.569 |
24 | Isoform 1 of Ficolin-3 | O75636 | 33.40 | 6.20 | 100 | 1.8743 |
25 | Isoform 2 of Ficolin-3 | O75636 | 32.11 | 6.36 | 100 | 1.9465 |
26 | Apolipoprotein L1 | E9PF24 | 42.19 | 5.58 | 96.777 | 1000000 |
27 | complement component 4B preproprotein | B4E344 | 194.17 | 6.89 | 99.987 | 2.1058 |
28 | DADB-112B14.11 Complement component 4B | B0UZ85 | 194.17 | 6.89 | 100 | 2.404 |
29 | IGK@ protein | Q6P5S8 | 26.04 | 5.94 | 99.398 | 2.004 |
30 | Peroxiredoxin-2 | P32119 | 22.05 | 5.66 | 100 | 9.686 |
31 | Ig kappa chain V-III region WOL | P01623 | 11.85 | 9.07 | 100 | 2.489 |
32 | Keratin, type II cytoskeletal 1 | P04264 | 66.17 | 8.15 | 99.112 | 2.4587 |
33 | Keratin, type II cytoskeletal 6C | P48668 | 60.27 | 8.09 | 100 | 2.5654 |
34 | Apolipoprotein A-1 | P02647 | 30.76 | 5.56 | 100 | 4.3662 |
35 | Serum amyloid P-component | P02743 | 25.49 | 6.10 | 100 | 3.863 |
36 | Retinol-binding protein 4 | P02753 | 23.34 | 5.76 | 100 | -2.876 |
37 | Haptoglobin beta chain | H0Y300 | 22.53 | 5.96 | 97.871 | 1.527 |
38 | HPR 47 kDa protein | P00738 | 47.38 | 6.28 | 100 | 1.7345 |