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Table 6 Multivariate analysis for independent risk factors for colistin-associated nephrotoxicity at day 7 and at the EOT

From: Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study

Day 7
Variable Odds ratio (95% CI) P
Age 1.01 (0.95-1.08) 0.75
Charlson score 1.04 (0.71-1.52) 0.84
Albumin 0.89 (0.33-2.42) 0.83
1CMS cumulative dose at day 7 0.99 (0.94-1.04) 0.73
2Cmin 4.7 (2.38-9.29) < 0.001
End of treatment
Variable Odds ratio (95% CI) P
Age 0.98 (0.93-1.03) 0.51
Charlson score 1.3 (1.01-1.57) 0.036
Albumin 0.59 (0.25-1.38) 0.22
CMS cumulative dose 0.99 (0.98-1) 0.38
CMS duration treatment 1.03 (0.98-1.08) 0.24
Cmin 2.1 (1.33-3.42) 0.002
3NSAID use 5.09 (0.9-28.54) 0.64
Loop diuretic use 1.97 (0.61-6.38) 0.25
Co-administration of > 2 nephrotoxic drugs 2.61 (1–6.7) 0.049
  1. 1CMS:colistinmethanesulfonate sodium. 2Cmin: colistin trough plasma concentrations at steady state. 3NSAID: non-steroidal anti-inflammatory drugs.
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