|
Variable
|
Colistin dosage regimen, n (%)
|
P
|
|---|
|
1 million IU/8 h (n = 28)
|
2 million IU/8 h (n = 42)
|
3 million IU/8 h (n = 16)
|
Other doses (n = 16)
|
|---|
|
Age (yrs)
|
74 (24–85)
|
67 (27–91)
|
55.5 (28–74)
|
73 (42–85)
|
0.023
|
|
N° (%) of male patients
|
22 (78.6)
|
32 (76.2)
|
14 (87.5)
|
11 (68.8)
|
0.64
|
|
Charlson score
|
4.8 ± 2.8
|
4.36 ± 2.6
|
3.7 ± 2.5
|
4.8 ± 2.1
|
0.41
|
|
N° (%) of severe sepsis
|
11 (39.3)
|
22 (52.4)
|
9 (56.3)
|
6 (37.5)
|
0.5
|
|
N° (%) septic shock
|
1 (3.6)
|
3 (7.1)
|
2 (12.5)
|
2 (12.5)
|
0.63
|
|
APACHE II
|
12.8 ± 6.7
|
11.9 ± 4.6
|
11.5 ± 4.45
|
13.7 ± 7.5
|
0.28
|
|
1CKD at baseline
|
12 (42.9)
|
7 (16.7)
|
1 (6.3)
|
11 (68.8)
|
<0.0001
|
|
Colistin dose (in 2CBA) in mg/kg/day (3IBW)
|
1.48 ± 0.3
|
2.9 ± 0.37
|
4.38 ± 0.9
|
1.54 ± 0.82
|
<0.0001
|
|
4Cmin
|
0.71 (0.2-2.01)
|
1.14 (0.11-5)
|
1.84 (0.45-5.99)
|
1.5 (0.16-3.02)
|
0.003
|
|
5Cmax
|
0.65 (0.24-1.99)
|
1.13 (0.15-5)
|
1.84 (0.5-6.62)
|
1.5 (0.16-3.7)
|
0.001
|
|
6CMS cumulative dose
|
58.5 ± 50.6
|
111.7 ± 85.9
|
171.5 ± 105.7
|
73.9 ± 111.3
|
<0.0001
|
|
CMS duration treatment
|
20 ± 16.5
|
19.5 ± 15.6
|
19.25 ± 8
|
19.2 ± 19.8
|
0.41
|
|
Concomitant antibiotics
|
15 (53.6)
|
23 (54.8)
|
10 (62.5)
|
8 (50)
|
0.9
|
|
7AKI at day 7
|
5 (17.9)
|
11 (26.2)
|
7 (43.8)
|
3 (18.8)
|
0.25
|
|
AKI at 8EOT
|
14 (50)
|
21 (50)
|
9 (56.3)
|
6 (37.5)
|
0.7
|
|
Clinical response
|
25 (89.3)
|
32 (76.2)
|
11 (68.8)
|
11 (68.8)
|
0.3
|
- Data are n (%) except where indicated.
- * Median (interquartile range).
- ** Mean ± SD.
-
1CKD: chronic kidney disease. 2CBA: colistin base activity. 3IBW: ideal body weight. 4Cmin: colistin trough plasma concentrations at steady state. 5Cmax: colistin maximum plasma concentrations at steady state. 6CMS: colistinmethanesulfonate sodium 7AKI: acute kidney injury. 8EOT: end of treatment.
