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Table 1 Genes significantly different between WT and Nlrc4−/− Lp-infected mice

From: Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila

Genes different between WT andNlrc4−/−mice

Name

Fold change (95% CI), p

Dbp

D site albumin promoter binding protein

0.05 (0.04-0.05), p = 6.62E-03

Tex11

Testis expressed gene 11

0.19 (0.16-0.21), p = 2.65E-03

Dbp

D site albumin promoter binding protein

0.04 (0.03-0.04), p = 5.62E-04

G530011O06Rik

RIKEN cDNA G530011O06 gene

46.41 (39.30-54.80), p = 2.51E-03

Genes different between WT infected and uninfected mice

Slc26a4

Solute carrier family 26, member 4

52.83 (46.51-60.02), p = 1.37E-05

Cd14

CD14 antigen

15.25 (13.64-17.06), p = 1.58E-05

Cxcl1

Chemokine (C-X-C motif) ligand 1

166.48 (147.58-187.81), p = 1.73E-05

Ereg

Epiregulin

11.31 (10.11-12.64), p = 2.07E-05

Gm1960

Gene model 1960, (NCBI)

383.16 (331.67-442.63), p = 2.07E-05

Cxcl1

Chemokine (C-X-C motif) ligand 1

56.19 (49.78-63.43), p = 2.07E-05

Steap4

STEAP family member 4

14.71 (13.02-16.63), p = 2.07E-05

G530011O06Rik

RIKEN cDNA G530011O06 gene

72.30 (61.82-84.56), p = 2.48E-05

Il4i1

Interleukin 4 induced 1

41.87 (33.79-51.89), p = 3.09E-05

Cxcl2

Chemokine (C-X-C motif) ligand 2

399.39 (355.05-449.26), p = 3.32E-05

Genes different between Nlrc4−/− infected and uninfected mice

Tbl3

Transducin (beta)-like 3

2.09 (1.85-2.37), p = 2.93E-03

Gja1

Gap junction membrane channel protein alpha 1

2.50 (2.22-2.81), p = 6.04E-04

Gja1

Gap junction membrane channel protein alpha 1

3.39 (3.04-3.78), p = 3.75E-04

Slc16a1

Solute carrier family 16 (monocarboxylic acid transporters), member 1

1.53 (1.29-1.80), p = 8.34E-03

Sfrs2

Splicing factor, arginine/serine-rich 2 (SC-35)

2.06 (1.79-2.37), p = 9.27E-04

Scd2

Stearoyl-Coenzyme A desaturase 2

0.55 (0.49-0.63), p = 3.51E-03

Scd2

Stearoyl-Coenzyme A desaturase 2

0.48 (0.43-0.54), p = 2.79E-03

Aldh18a1

Aldehyde dehydrogenase 18 family, member A1

1.86 (1.66-2.08), p = 6.23E-03

Junb

Jun-B oncogene

5.19 (4.66-5.79), p = 2.32E-04

Marcksl1

MARCKS-like 1

4.94 (4.44-5.50), p = 2.31E-04

  1. Depicted above are the top ten most significant genes differentially expressed in 1) Nlrc4−/− vs Tlr5−/−, 2) WT infected and uninfected and 3) Nlrc4−/− infected and uninfected as determined by a general linear model using a false discovery rate of 0.05.
  2. Complete gene lists are included in online supplemental material to highlight similarities between probes differentially regulated between WT and NLRC4−/− infected lungs.
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BMC Infectious Diseases

ISSN: 1471-2334

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