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Table 1 Genes significantly different between WT and Nlrc4−/− Lp-infected mice

From: Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila

Genes different between WT andNlrc4−/−mice Name Fold change (95% CI), p
Dbp D site albumin promoter binding protein 0.05 (0.04-0.05), p = 6.62E-03
Tex11 Testis expressed gene 11 0.19 (0.16-0.21), p = 2.65E-03
Dbp D site albumin promoter binding protein 0.04 (0.03-0.04), p = 5.62E-04
G530011O06Rik RIKEN cDNA G530011O06 gene 46.41 (39.30-54.80), p = 2.51E-03
Genes different between WT infected and uninfected mice
Slc26a4 Solute carrier family 26, member 4 52.83 (46.51-60.02), p = 1.37E-05
Cd14 CD14 antigen 15.25 (13.64-17.06), p = 1.58E-05
Cxcl1 Chemokine (C-X-C motif) ligand 1 166.48 (147.58-187.81), p = 1.73E-05
Ereg Epiregulin 11.31 (10.11-12.64), p = 2.07E-05
Gm1960 Gene model 1960, (NCBI) 383.16 (331.67-442.63), p = 2.07E-05
Cxcl1 Chemokine (C-X-C motif) ligand 1 56.19 (49.78-63.43), p = 2.07E-05
Steap4 STEAP family member 4 14.71 (13.02-16.63), p = 2.07E-05
G530011O06Rik RIKEN cDNA G530011O06 gene 72.30 (61.82-84.56), p = 2.48E-05
Il4i1 Interleukin 4 induced 1 41.87 (33.79-51.89), p = 3.09E-05
Cxcl2 Chemokine (C-X-C motif) ligand 2 399.39 (355.05-449.26), p = 3.32E-05
Genes different between Nlrc4−/− infected and uninfected mice
Tbl3 Transducin (beta)-like 3 2.09 (1.85-2.37), p = 2.93E-03
Gja1 Gap junction membrane channel protein alpha 1 2.50 (2.22-2.81), p = 6.04E-04
Gja1 Gap junction membrane channel protein alpha 1 3.39 (3.04-3.78), p = 3.75E-04
Slc16a1 Solute carrier family 16 (monocarboxylic acid transporters), member 1 1.53 (1.29-1.80), p = 8.34E-03
Sfrs2 Splicing factor, arginine/serine-rich 2 (SC-35) 2.06 (1.79-2.37), p = 9.27E-04
Scd2 Stearoyl-Coenzyme A desaturase 2 0.55 (0.49-0.63), p = 3.51E-03
Scd2 Stearoyl-Coenzyme A desaturase 2 0.48 (0.43-0.54), p = 2.79E-03
Aldh18a1 Aldehyde dehydrogenase 18 family, member A1 1.86 (1.66-2.08), p = 6.23E-03
Junb Jun-B oncogene 5.19 (4.66-5.79), p = 2.32E-04
Marcksl1 MARCKS-like 1 4.94 (4.44-5.50), p = 2.31E-04
  1. Depicted above are the top ten most significant genes differentially expressed in 1) Nlrc4−/− vs Tlr5−/−, 2) WT infected and uninfected and 3) Nlrc4−/− infected and uninfected as determined by a general linear model using a false discovery rate of 0.05.
  2. Complete gene lists are included in online supplemental material to highlight similarities between probes differentially regulated between WT and NLRC4−/− infected lungs.