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Figure 5 | BMC Infectious Diseases

Figure 5

From: Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila

Figure 5

NLRC4 deficiency impairs replication in murine alveolar macrophages. Alveolar macrophages (AM) were isolated from lungs of WT (A), Nlrc4−/− (B), and Tlr5−/− (C) mice by bronchoalveolar lavage of uninfected mice. Cells were infected ex vivo with WT (Corby) Lp or isogenic FlaA- (Corby) Lp and CFUs were measured in lysed monolayers at 24, 48, and 72 hours. Data are mean ± SEM of triplicate or quadruplicate monolayers at each time point (except for duplicate measures at time 0 from TLR5−/− mice.). *p < 0.05, †p < 0.005 as determined by two-tailed Students’ t-test.

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