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Table 1 In vitro antifungal susceptibility testing of 240 clinical isolates to 6 antifungal agents

From: Surveillance of the prevalence, antibiotic susceptibility, and genotypic characterization of invasive candidiasis in a teaching hospital in China between 2006 to 2011

Species (No of isolates) Antifungal agent MIC (μg/ml) % Resistant
   Range MIC50 a MIC90 a  
All isolates (240) Fluconazole 1– > 128 1 4 7.5
Voriconazole(except C. glabrata) 0.06– > 8 0.064 0.25 5.4
Itraconazole(limit C.albicans only) 0.125– > 4 0.125 0.5 4.9
Caspofunginb 0.032–2 0.125 0.5 0
Flucytosine < 4–16 4 4  
Amphotericin B < 0.5–0.5 0.5 0.5  
C. albicans (136) Fluconazole 1– > 128 1 2 6.6
Voriconazole 0.06– > 8 0.064 0.064 2.9
Itraconazole 0.125– > 4 0.125 0.125 4.9
Caspofunginb 0.032–0.38 0.094 0.19 0
Flucytosine < 4–16 4 4  
Amphotericin B < 0.5–0.5 0.5 0.5  
C.tropicalis (59) Fluconazole 1– > 128 1 128 10.6
Voriconazole 0.06– > 8 0.064 8 10.6
Itraconazole 0.125– > 4 0.125 4  
Caspofunginb 0.032–0.38 0.094 0.19 0
Flucytosine < 4–4 4 4  
Amphotericin B < 0.5–0.5 0.5 0.5  
C. paraps-ilosis (25) Fluconazole < 1–2 1 1 0
Voriconazole < 0.06–0.25 0.064 0.064 0
Itraconazole < 0.125–0.25 0.125 0.125  
Caspofunginb 0.38–2 1 1.5 0
Flucytosine < 4– > 16 4 16  
Amphotericin B < 0.5–0.5 0.5 0.5  
C.glabrata (20) Fluconazole 1–64 2 64 15.0
Voriconazole 0.06–8 0.125 8  
Itraconazole 0.125– > 4 0.5 4  
Caspofunginb 0.047–0.38 0.19 0.25 0
Flucytosine < 4–4 4 4  
  Amphotericin B < 0.5–0.5 0.5 0.5  
  1. Footnote: aMIC50, 50% minimal inhibitory concentration; MIC90: 90% minimal inhibitory concentration. bCaspofungin tested using E-test strips.