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Table 3 Results of the performance of the original clinical model compared with that of different models extended with genetic variables selected by the lasso method

From: Addition of host genetic variants in a prediction rule for post meningitis hearing loss in childhood: a model updating study

SNP / SNP combination Log likelihood values AUC of ROC 95% CI of AUC of ROC p-valuea
Clinical model   0.856 0.794-0.909  
TLR4 0.2802 0.854 0.786-0.911 0.780
TLR9 -1237 −0.5675 0.861 0.798-0.915 0.570
NOD2 - SNP13 0.8338 0.855 0.796-0.908 0.404
TLR2+ 2477 and TLR4 −0.9646 0.875 0.816-0.925 0.335
TLR2 -19634 and TLR4 −0.8836 0.869 0.812-0.920 0.377
TLR2+ 2477 and TLR9+ 2848 0.0843 0.855 0.780-0.918 0.933
  1. a AUC combined SNP model versus clinical model.
  2. Abbreviations:
  3. SNP: Single nucleotide polymorphism.
  4. AUC: Area Under the Curve.
  5. ROC: Receiver Operator Curve.
  6. 95% CI: 95% confidence interval.
  7. TLR: Toll-like receptor.
  8. NOD: Nucleotide Oligomerization Domain protein.