Figure 4

Implications of changing vaccine efficacy or transmission intensity on impact. The impact of vaccine efficacy and transmission setting on the potential number of uncomplicated malaria cases averted annually over a 10-year period of vaccine use. The demonstration scenario of 85% efficacy and a transmission setting in which the risk level (EIR category) of one-quarter of the population at risk was reduced averted the most cases (●), followed by 85% efficacy at a setting in which the risk level of one-half the population at risk was reduced (▲), 75% efficacy at the transmission setting in which one-quarter of the population experienced reduced risk (■), and 75% efficacy at a transmission setting in which one-half the population at risk experienced a reduction in transmission (×).