Table 4 Univariate analysis of the association between subclinical atherosclerosis and other factors related to HIV, by age group, seen at two referral hospitals in the state of Pernambuco, Brazil
Variables | < 40 years old (n=351) | ≥ 40 years old (n=346) | ||||
|---|---|---|---|---|---|---|
% subclinical atherosclerosis | OR(CI) | p-value | % subclinical atherosclerosis | OR(CI) | p-value | |
Time elapsed since HIV diagnosis (years ) | ||||||
< 1 | 19.3 | 1.0 | - | 55.1 | 1.0 | - |
1 to < 5 | 22.3 | 1.19 (0.64 – 2.25) | 0.570 | 65.8 | 1.56 (0.81 – 3.01) | 0.179 |
≥5 | 30.5 | 1.82 (0.91 – 3.66) | 0.090 | 70.6 | 1.95 (0.99 – 3.83) | 0.051 |
Clinical history of AIDS | ||||||
No | 24.0 | 1.0 | - | 65.7 | 1.0 | - |
Yes | 24.2 | 1.01 (0.58 – 1.76) | 0.975 | 72.7 | 1.38 (0.68 – 2.81) | 0.362 |
CD4+ T-lymphocytes (cells/mm 3 ) | ||||||
< 200 | 22.2 | 1.0 | - | 53.3 | 1,0 | - |
200 to < 350 | 24.4 | 1.12 (0.51 – 2.48) | 0.763 | 63.1 | 1.49 (0.81 – 2.74) | 0.193 |
350 and more | 21.9 | 0.98 (0.42 – 2.30) | 0.963 | 84.0 | 4.59 (2.19 – 9.59) | 0.000 |
Viral load (copies/mL) | ||||||
< 50 | 29.4 | 1.0 | - | 67.5 | 1.0 | - |
50 to < 10,000 | 24.6 | 0.78 (0.34 – 1.81) | 0.566 | 62.7 | 0.89 (0.41-1.91) | 0.767 |
10,000 < 100,000 | 19.4 | 0.58 (0.21 – 1.61) | 0.295 | 72.7 | 1.61 (0.54-4.73) | 0.384 |
> 100,000 | 15.4 | 0.44 (0.09 – 2.21) | 0.316 | 68.6 | 1.07 (0.32-3.55) | 0.905 |
HAART use | ||||||
No | 19.9 | 1.0 | - | 59.5 | 1.0 | - |
Yes | 26.0 | 1.42 (0.85 – 2.36) | 0.184 | 68.9 | 1.50 (0.91 – 2.48) | 0.109 |
Types HAART regimens | ||||||
No HAART use | 19.9 | 1.0 | - | 59.5 | 1.0 | - |
PI | 17.1 | 0.83 (0.40 – 1.71) | 0.619 | 59.3 | 0.99 (0.54 – 1.79) | 0.977 |
NNRTI | 31.2 | 1.83 (1.05 – 3.19) | 0.031 | 74.2 | 1.95 (1.12 – 3.39) | 0.017 |
HAART duration of use (years) | ||||||
No HAART use | 19.9 | 1.0 | - | 59.5 | 1.0 | - |
< 5 | 24.7 | 1.32 (0.78 - 2.25) | 0.299 | 64.2 | 1.21 (0.72 – 2.06) | 0.460 |
≥ 5 | 34.6 | 2.13 (0.86 – 5.27) | 0.100 | 81.6 | 3.00 (1.46 – 6.16) | 0.003 |