Table 3 Univariate analysis of the association between subclinical atherosclerosis and socio-demographic variables, habits, and metabolic data in individuals infected with HIV by age group, seen at two referral hospitals in the state of Pernambuco, Brazil
Variables | < 40 years old (n=351) | ≥ 40 years old (n=346) | ||||
|---|---|---|---|---|---|---|
% subclinical atherosclerosis | OR(CI) | p-value | % subclinical atherosclerosis | OR(CI) | p-value | |
Age (continuous) | - | 1.17 (1.10 – 1.25) | < 0.001 | - | 1.11 (1.06 – 1.16) | < 0.001 |
Gender | ||||||
Female | 18.3 | 1.0 | - | 62,7 | 1.0 | - |
Male | 26.8 | 1.63 (0.96 – 2.75) | 0.067 | 69.2 | 1.33 (0.84 – 2.09) | 0.213 |
Race | ||||||
White | 13.3 | 1.0 | - | 68.2 | 1.0 | - |
Nonwhite | 26.8 | 2.38 (1.22 – 4.64) | 0.011 | 65.9 | 0.89 (0.53 – 1.52) | 0.691 |
Schooling (years of study) | ||||||
1 to 12 | 22.3 | 1.0 | - | 66.4 | 1.0 | - |
13 or more | 32.3 | 1.67 (0.77 – 3.59) | 0.190 | 68.3 | 1.10 (0.58 – 2.10) | 0.759 |
Stable partner | ||||||
No | 20.1 | 1.0 | - | 62.5 | 1.0 | - |
Yes | 36.8 | 2.30 (1.30 – 4.08) | 0.004 | 78.6 | 2.19 (1.23 – 3.91) | 0.008 |
Smoking | ||||||
No | 24.4 | 1.0 | - | 66.4 | 1.0 | - |
Yes | 19.8 | 0.87 (0.36 – 2.09) | 0.759 | 66.7 | 0.97 (0.46 – 1.93) | 0.929 |
Lipodystrophy | ||||||
No | 20.6 | 1.0 | - | 63.5 | 1.0 | - |
Yes | 28.0 | 1.50 (0.88 – 2.54) | 0.131 | 70.2 | 1.35 (0.84 – 2.17) | 0.206 |
Metabolic Syndrome | ||||||
No | 17.9 | 1.0 | - | 63.9 | 1.0 | - |
Yes | 49.1 | 4.42 (2.44 – 7.99) | 0,000 | 72.0 | 1.44 (0.87 – 2.38) | 0.147 |
Hypertension | ||||||
No | 19.1 | 1.0 | - | 61.0 | 1.0 | - |
Yes | 44.3 | 3.36 (1.87 – 6.03) | 0.000 | 76.9 | 2.12 (1.28 – 3.52) | 0.004 |
Waist circumference (cm) | ||||||
Normal | 19.2 | 1.0 | - | 62.3 | 1.0 | - |
Abnormal* | 41.2 | 2.94 (1.66 – 5.18) | 0.000 | 74.7 | 1.64 (0.93 – 2.89) | 0.087 |
BMI (kg/m 2 ) | ||||||
< 25 | 15.5 | 1.0 | - | 60.0 | 1.0 | - |
≥ 25 and < 30 | 32.6 | 2.63 (1.49 – 4.67) | 0.001 | 75.2 | 2.02 (1.19 – 3.42) | 0.008 |
≥ 30 | 52.9 | 6.14 (2.86 – 13.2) | 0.000 | 81.2 | 2.88 (1.13 – 7.32) | 0.025 |
Total cholesterol (mg/dL) | ||||||
< 200 | 21.7 | 1.0 | - | 62.6 | 1.0 | - |
200 - <240 | 28.6 | 1.44 (0.69 – 2.98) | 0.323 | 69.4 | 1.35 (0.79 – 2.32) | 0.269 |
≥ 240 | 42.1 | 2.62 (1.01 – 6.80) | 0.048 | 83.0 | 2.89 (1.22 – 6.84) | 0.015 |
HDL-cholesterol (mg/dL) ** | ||||||
Normal | 24.8 | 1.0 | - | 64.8 | 1.0 | - |
Low | 22.4 | 0.87 (0.52 – 1.44) | 0.596 | 67.7 | 1.13 (0.72 – 1.79) | 0.579 |
LDL-cholesterol (mg/dL) | ||||||
< 130 | 22.2 | 1.0 | - | 61.5 | 1.0 | - |
≥ 130 | 30.4 | 1.53 (0.77 – 3.05) | 0.225 | 82.9 | 3.02 (1.58 – 5.82) | 0.001 |
Triglycerides (mg/dL) | ||||||
< 150 | 18.9 | 1.0 | - | 63.9 | 1.0 | - |
≥ 150 | 31.4 | 1.96 (1.17 - 3.28) | 0.010 | 69.3 | 1.27 (0.80 – 2.01) | 0.296 |
Fasting glucose (mg/dL) | ||||||
< 100 | 21.6 | 1.0 | - | 65.6 | 1.0 | - |
≥ 100 | 35.7 | 2.01 (1.01 – 4.01) | 0.046 | 72.4 | 1.39 (0.81 – 2.38) | 0.227 |