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Table 4 Comparison of median and interquartile range of plasma efavirenz (EFV) concentrations (mg/L) between patients treated with EFV based HAART only (EFV only) versus TB-HIV coinfected patients treated with EFV based HAART plus RIF based TB therapy (EFV + RIF) stratified by observed neuropsychiatric symptoms during therapy (Yes) and who did not (No) during therapy
| Neuropsychiatric disorders (No) | Neuropsychiatric disorders (Yes) | |||||||
|---|---|---|---|---|---|---|---|---|
| EFV only | EFV + RIF | EFV only | EFV + RIF | |||||
| N | Median (IQR) | N | Median (IQR) | N | Median (IQR) | N | Median (IQR) | |
| Day-3 | 15 | 2.29 (1.41-2.88) | 22 | 1.48 (1.15-1.88) | 41 | 2.6 (2.09-2.94) | 84 | 1.97 (1.38-2.91) |
| week-1 | 13 | 2.25 (1.84-2.69) | 15 | 1.53 (1.28-1.97) | 39 | 2.47 (2.09-3.23) | 41 | 1.9 (1.34-2.61) |
| week-2 | 15 | 1.9 (1.27-2.3) | 25 | 1.66 (1.36-2.11) | 37 | 2.51 (1.84-3.43) | 74 | 2.05 (1.4-2.67) |
| week-4 | 12 | 1.64 (1.46-2.43) | 28 | 1.57 (1.19-2.17) | 36 | 2.65 (2.05-3.56) | 74 | 2.37 (1.55-3.57) |
| week-6 | 12 | 2.11 (1.46-3.41) | 24 | 1.77 (1.37-2.02) | 25 | 2.43 (1.94-3.51) | 61 | 2.17 (1.66-4.63) |
| week-8 | 14 | 1.69 (1.41-2.49) | 31 | 1.56 (1.34-3.05) | 35 | 2.48 (2.23-3.13) | 86 | 1.91 (1.48-3.22) |
| week-12 | 12 | 1.86 (1.45-2.26) | 29 | 1.84 (1.45-2.7) | 31 | 2.61 (2.04-4.09) | 70 | 2.29 (1.56-4.45) |
