Table 2 Serological assay interpretation per the Novagnost assay
VCA IgM | VCA IgG | EBNA-1 | Patient status | Alternative interpretation |
|---|---|---|---|---|
– | – | – | Probably not infecteda | |
+ | – | – | Primary early phase infection | ● Possible cross-reactivity with primary CMV infection IgM |
+ | + | – | Primary acute infection | |
– | + | + | Past infection | |
– | + | – | Uncertain result | ● Primary infection without VCA IgM |
● Past infection with EBNA loss | ||||
– | – | + | Uncertain result | Very rare profile of past infection: |
● Possible loss of VCA IgG | ||||
● Possible EBNA false positive | ||||
+ | + | + | Uncertain result | ● Just past primary infection |
● Viral reactivation | ||||
● Cross-reaction with CMV primary infection IgM | ||||
● Nonspecific polyclonal IgM stimulation from a previous cross-reacting | ||||
● infectious agent |