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Table 2 Serological assay interpretation per the Novagnost assay

From: Reliability of the Siemens Enzygnost and Novagnost Epstein–Barr Virus assays for routine laboratory diagnosis: agreement with clinical diagnosis and comparison with the Merifluor Epstein–Barr Virus immunofluorescence assay

VCA IgM VCA IgG EBNA-1 Patient status Alternative interpretation
Probably not infecteda  
+ Primary early phase infection Possible cross-reactivity with primary CMV infection IgM
+ + Primary acute infection  
+ + Past infection  
+ Uncertain result Primary infection without VCA IgM
Past infection with EBNA loss
+ Uncertain result Very rare profile of past infection:
Possible loss of VCA IgG
Possible EBNA false positive
+ + + Uncertain result Just past primary infection
Viral reactivation
Cross-reaction with CMV primary infection IgM
Nonspecific polyclonal IgM stimulation from a previous cross-reacting
infectious agent
  1. a Retest in 7 days.