Table 4 Parameter Values
Parameter | Age group (years) | |||||
|---|---|---|---|---|---|---|
0- < 2 | 2-4 | 5-17 | 18-49 | 50-64 | 65+ | |
Annual non-pandemic baseline incidence rates / 100,000 a | ||||||
Pneumococcal meningitis | 3.54 | 0.98 | 0.27 | 0.71 | 1.37 | 2.39 |
Pneumococcal bacteremia | 33.9 | 13.2 | 2.16 | 6.97 | 18.5 | 35.5 |
All-cause pneumonia | 8,749 | 7,752 | 1,648 | 750 | 328 | 2,163 |
Percent of meningitis that results in deafness b | 13% | 13% | 6% | 13% | 13% | 13% |
Percent of meningitis that results in disability b | 7% | 7% | 5% | 7% | 7% | 7% |
Case-Fatality Rates | ||||||
Pneumococcal meningitisc | 6.9% | 4.0% | 10.0% | 10.4% | 11.4% | 23.8% |
Pneumococcal bacteremiac | 0.9% | 0.4% | 4.2% | 6.2% | 11.3% | 15.7% |
All-cause hospitalized pneumoniad | 0.4% | 0.2% | 0.3% | 1.2% | 2.5% | 6.3% |
Direct effects (% reduction in disease at time of vaccination) e | ||||||
IPD | 49.8% | -- | -- | -- | -- | -- |
All-cause hospitalized pneumonia | 16.2% | -- | -- | -- | -- | -- |
vAll-cause non-hospitalized pneumonia | 3.8% | -- | -- | -- | -- | -- |
Indirect effects (% reduction in disease) f | ||||||
IPD | 32.7% | 39.4% | 34.4% | 34.5% | 24.5% | 27.4% |
All-cause hospitalized pneumonia | 22.5% | 0.0% | 9.2% | 11.3% | 8.7% | 6.9% |
All-cause non-hospitalized pneumonia | 6.2% | 0.0% | 4.7% | 5.9% | 3.7% | 3.4% |
Direct Medical Costs ($2008) | ||||||
Meningitis episodeg | $17,048 | $17,048 | -- | -- | -- | -- |
Bacteremia episodeg | $3,253 | $3,253 | -- | -- | -- | -- |
Cost of invasive disease episodeg | -- | -- | $12,738 | $17,956 | $22,135 | $17,216 |
Lifetime cost of deafnessh | $96,788 | $96,788 | $91,663 | $73,530 | $48,435 | $35,261 |
Lifetime cost of disabilityh | $499,409 | $499,409 | $472,965 | $379,402 | $249,915 | $181,940 |
Hospitalized pneumonia episodeh | $7,276 | $7,276 | $4,994 | $9,248 | $10,148 | $9,872 |
Non-hospitalized pneumonia episodei | $233 | $233 | $308 | $308 | $308 | $308 |
Vaccine Price (per dose) | ||||||
PCV7 | $73 | -- | -- | -- | -- | -- |
PCV13 | $100 | -- | -- | -- | -- | -- |
Vaccine administration | $11 | -- | -- | -- | -- | -- |
QALY Inputs (all ages) j,k | Meningitis | Bacteremia | Hospitalized Pneumonia | Non-Hospitalized Pneumonia | Deafness (utility) | Disability (utility) |
0.023 | 0.008 | 0.006 | 0.004 | 0.73 | 0.68 | |