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Table 6 Association between maternal cytokine gene polymorphisms and antibody levels to P. falciparum antigens in newborns: multivariate analysis

From: Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

Antibody response Maternal cytokine gene (n) Antibody levels (μg/ml)a(SD) P
IgG to AMA-1    
  IL-10 −1082 genotypes:   
 GG and GA (270) 1497.3 (214.0)  
 AA (306) 1638.9 (68.3) 0.04 b
  IL-13 −1055 genotypes:   
 CC and CT (481) 1596.0 (230.8)  
 TT (95) 1444.0 (69.9) 0.03 b
IgG to MSP-2/3D7    
  IL-10 −1082 genotypes:   
 GG and GA (270) 46.0 (4.1)  
 AA (306) 57.6 (6.5) 0.08 c
IgG to GLURP-R0    
  IL-10 −592 genotypes:   
 CC and CA (485) 3.2 (0.3)  
 AA (91) 2.2 (0.5) 0.06 c
  IL-10 −1082 /IL-10 −819 /IL-10 −592 haplotypes:   
   No or 1 copy IL10-ATA (489) 3.2 (0.3)  
   2 copies IL10-ATA (87) 2.2 (0.5) 0.05 c
  1. a median value.
  2. b analysis adjusted on maternal age, parity and estimated exposure to malaria transmission during pregnancy.
  3. c analysis adjusted on presence of P. falciparum circulating parasites in mothers.
  4. P values < 0.05 are in bold.