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Table 3 Frequency of HLA-A, -B and –DRB1 alleles in ACL Group 1 and the control group

From: Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

  ACL (group 1) (n = 136) Controls (n = 260)       ACL (group 1) (n = 136) Controls (n = 260)     
Allele n F % n F % P -value P c-value OR 95%CI Allele n F % n F% P -value P c–value OR 95%CI
HLA – A*          HLA-B*         
01 29 10.7 47 9.0 ns -    07 15 5.5 38 7.3 ns -   
02 73 26.8 127 24.4 ns -    08 10 3.7 34 6.5 ns -   
03 24 8.8 56 10.8 ns -    13 1 0.4 9 1.7 ns -   
11 18 6.6 26 5.0 ns -    14 14 5.2 22 4.2 ns -   
23 14 5.2 22 4.2 ns -    15 23 8.5 48 9.2 ns -   
24 28 10.3 62 11.9 ns -    18 13 4.8 36 6.9 ns -   
25 4 1.5 13 2.5 ns -    27 3 1.1 8 1.5 ns -   
26 8 2.9 18 3.5 ns -    35 53 19.5 68 13.1 0.0218 0.6758 1.67 1.08-2.29
29 9 3.3 28 5.4 ns -    37 1 0.4 5 1.0 ns -   
30 9 3.3 25 4.8 ns -    38 7 2.6 15 2.9 ns -   
31 15 5.5 19 3.7 ns -    39 10 3.7 18 3.5 ns -   
32 7 2.6 16 3.1 ns -    40 14 5.2 16 3.1 ns -   
33 5 1.8 15 2.9 ns -    41 2 0.7 6 1.2 ns -   
34 3 1.1 5 1.0 ns -    42 2 0.7 6 1.2 ns -   
36 1 0.4 2 0.4 ns -    44 38 14.0 46 8.9 0.0290 0.8990 1.67 1.05-2.64
39 1 0.4 - - ns -    45 0 - 12 2.3 0.0107 0.3317 - -
66 2 0.7 1 0.2 ns -    46 0 - 4 0.8 ns -   
68 19 7.0 35 6.7 ns -    47 0 - 1 0.2 ns -   
74 3 1.1 3 0.6 ns -    48 3 1.1 2 0.4 ns -   
HLA-DRB1*          49 4 1.5 8 1.5 ns -   
01 18 6.6 42 8.1 ns -    50 6 2.2 14 2.7 ns -   
03 22 8.1 61 11.7 ns -    51 24 8.8 44 8.5 ns -   
04 33 12.1 56 10.8 ns -    52 6 2.2 11 2.1 ns -   
07 33 12.1 67 12.9 ns -    53 7 2.6 8 1.5 ns -   
08 20 7.4 30 5.8 ns -    54 0 - 3 0.6 ns -   
09 4 1.5 4 0.8 ns -    55 5 1.8 12 2.3 ns -   
10 5 1.8 10 1.9 ns -    56 1 0.3 1 0.2 ns -   
11 33 12.1 81 15.6 ns -    57 5 1.8 12 2.3 ns -   
12 3 1.1 10 1.9 ns -    58 5 1.8 10 1.9 ns -   
13 44 16.2 54 10.4 0.0228 0.3420 1.66 1.08-2.55 73 0 - 1 0.2 ns -   
14 14 5.2 40 7.7 ns -    81 0 - 2 3.9 ns -   
15 28 10.3 44 8.8 ns -            
16 15 5.5 21 4.0 ns -            
  1. n = number of times the allele occurs; F = allele frequency; P-value = calculated by Fisher’s exact test; Pc-value = value of P corrected by Bonferroni correction; OR = odds ratio; 95%CI = 95% confidence interval; ns= not significant (p > 0.05).