Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

BMC Infectious Diseases

Table 3 Frequency of HLA-A, -B and –DRB1 alleles in ACL Group 1 and the control group

	ACL (group 1) (n = 136)		Controls (n = 260)							ACL (group 1) (n = 136)		Controls (n = 260)
Allele	n	F %	n	*F %*	P -value	P c-value	OR	95%CI	Allele	n	*F %*	n	F%	P -value	P c–value	OR	95%CI
HLA – A*									HLA-B*
01	29	10.7	47	9.0	ns	-			07	15	5.5	38	7.3	ns	-
02	73	26.8	127	24.4	ns	-			08	10	3.7	34	6.5	ns	-
03	24	8.8	56	10.8	ns	-			13	1	0.4	9	1.7	ns	-
11	18	6.6	26	5.0	ns	-			14	14	5.2	22	4.2	ns	-
23	14	5.2	22	4.2	ns	-			15	23	8.5	48	9.2	ns	-
24	28	10.3	62	11.9	ns	-			18	13	4.8	36	6.9	ns	-
25	4	1.5	13	2.5	ns	-			27	3	1.1	8	1.5	ns	-
26	8	2.9	18	3.5	ns	-			35	53	19.5	68	13.1	0.0218	0.6758	1.67	1.08-2.29
29	9	3.3	28	5.4	ns	-			37	1	0.4	5	1.0	ns	-
30	9	3.3	25	4.8	ns	-			38	7	2.6	15	2.9	ns	-
31	15	5.5	19	3.7	ns	-			39	10	3.7	18	3.5	ns	-
32	7	2.6	16	3.1	ns	-			40	14	5.2	16	3.1	ns	-
33	5	1.8	15	2.9	ns	-			41	2	0.7	6	1.2	ns	-
34	3	1.1	5	1.0	ns	-			42	2	0.7	6	1.2	ns	-
36	1	0.4	2	0.4	ns	-			44	38	14.0	46	8.9	0.0290	0.8990	1.67	1.05-2.64
39	1	0.4	-	-	ns	-			45	0	-	12	2.3	0.0107	0.3317	-	-
66	2	0.7	1	0.2	ns	-			46	0	-	4	0.8	ns	-
68	19	7.0	35	6.7	ns	-			47	0	-	1	0.2	ns	-
74	3	1.1	3	0.6	ns	-			48	3	1.1	2	0.4	ns	-
HLA-DRB1*									49	4	1.5	8	1.5	ns	-
01	18	6.6	42	8.1	ns	-			50	6	2.2	14	2.7	ns	-
03	22	8.1	61	11.7	ns	-			51	24	8.8	44	8.5	ns	-
04	33	12.1	56	10.8	ns	-			52	6	2.2	11	2.1	ns	-
07	33	12.1	67	12.9	ns	-			53	7	2.6	8	1.5	ns	-
08	20	7.4	30	5.8	ns	-			54	0	-	3	0.6	ns	-
09	4	1.5	4	0.8	ns	-			55	5	1.8	12	2.3	ns	-
10	5	1.8	10	1.9	ns	-			56	1	0.3	1	0.2	ns	-
11	33	12.1	81	15.6	ns	-			57	5	1.8	12	2.3	ns	-
12	3	1.1	10	1.9	ns	-			58	5	1.8	10	1.9	ns	-
13	44	16.2	54	10.4	0.0228	0.3420	1.66	1.08-2.55	73	0	-	1	0.2	ns	-
14	14	5.2	40	7.7	ns	-			81	0	-	2	3.9	ns	-
15	28	10.3	44	8.8	ns	-
16	15	5.5	21	4.0	ns	-

n = number of times the allele occurs; F = allele frequency; P-value = calculated by Fisher’s exact test; Pc-value = value of P corrected by Bonferroni correction; OR = odds ratio; 95%CI = 95% confidence interval; ns= not significant (p > 0.05).

ISSN: 1471-2334