|
Characteristics
|
No infiltrate and no bacteraemia patients
|
Infiltrate without bacteraemia patients
|
Bacteraemia patients
|
|---|
| |
n (%) a
|
PR (95% CI)
|
n (%) a
|
PR (95% CI)
|
n (%) a
|
PR (95% CI)
|
|---|
|
Medical ward
|
188 (97)
|
1.0 (ref.)
|
229 (92)
|
0.9 (0.9-1.0)
|
249 (95)
|
1.0 (0.9-1.0)
|
|
Community acquired b
|
167 (87)
|
1.0 (ref.)
|
217 (87)
|
1.0 (0.9-1.1)
|
242 (92)
|
1.1 (1.0-1.1)
|
|
Antibiotics
|
155 (80)
|
1.0 (ref.)
|
235 (94)
|
1.2 (1.1-1.3)
|
260 (99)
|
1.2 (1.2-1.3)
|
|
Aetiology
|
| |
Pneumococcal only
|
137 (71)
|
1.0 (ref.)
|
178 (71)
|
1.0 (0.9-1.1)
|
219 (84)
|
1.2 (1.1-1.3)
|
| |
Pneumococcal mixed c
|
56 (29)
|
1.0 (ref.)
|
72 (29)
|
1.0 (0.7-1.3)
|
43 (16)
|
0.6 (0.4-0.8)
|
|
Respiratory symptoms d
|
| |
0
|
0 (0)
|
1.0 (ref.)
|
20 (8)
|
NA
|
35 (13)
|
NA
|
| |
1
|
33 (17)
|
1.0 (ref.)
|
25 (10)
|
0.6 (0.4-0.9)
|
56 (21)
|
1.3 (0.8-1.8)
|
| |
2
|
44 (23)
|
1.0 (ref.)
|
59 (24)
|
1.0 (0.7-1.5)
|
79 (30)
|
1.3 (1.0-1.8)
|
| |
≥3
|
116 (60)
|
1.0 (ref.)
|
146 (58)
|
1.0 (0.8-1.1)
|
92 (36)
|
0.6 (0.5-0.7)
|
|
Oxygen saturation (peripheral)
|
94 (91–96)
| |
92 (88–95)
| |
93 (89–95)
| |
|
Temperature ≥38.5°C
|
35 (20)
|
1.0 (ref.)
|
86 (37)
|
1.8 (1.3-2.6)
|
126 (50)
|
2.5 (1.8-3.4)
|
|
MAP (mmHg)
|
91 (78–103)
| |
88 (73–99)
| |
80 (72–97)
| |
|
CURB65 ≥2
|
68 (35)
|
1.0 (ref.)
|
121 (48)
|
1.4 (1.1-1.7)
|
160 (61)
|
1.7 (1.4-2.1)
|
|
PITT ≥4
|
12 (6)
|
1.0 (ref.)
|
28 (11)
|
1.8 (0.9-3.4)
|
41 (16)
|
2.5 (1.4-4.7)
|
|
CRP (mg/L)
|
| |
Median
|
82 (36–140)
| |
163 (70–246)
| |
316 (219–404)
| |
| |
<50
|
54 (31)
|
1.0 (ref.)
|
41 (17)
|
0.6 (0.4-0.8)
|
8 (3)
|
0.1 (0.1-0.2)
|
| |
50-99
|
46 (26)
|
1.0 (ref.)
|
36 (15)
|
0.6 (0.4-0.9)
|
14 (6)
|
0.2 (0.1-0.4)
|
| |
100-199
|
52 (30)
|
1.0 (ref.)
|
68 (29)
|
1.0 (0.7-1.3)
|
32 (13)
|
0.4 (0.3-0.6)
|
| |
≥200
|
24 (14)
|
1.0 (ref.)
|
91 (39)
|
2.8 (1.9-4.2)
|
196 (78)
|
5.7 (3.9-8.4)
|
|
Leukocyte count (109/L)
|
| |
Median
|
14 (11–17)
| |
14 (11–19)
| |
17 (12–23)
| |
| |
<3,5
|
3 (1)
|
1.0 (ref.)
|
8 (3)
|
6.1 (0.8-48.0)
|
17 (7)
|
12.2 (1.6-90.5)
|
| |
3.5-8.7
|
17 (10)
|
1.0 (ref.)
|
25 (11)
|
1.1 (0.6-2.0)
|
22 (9)
|
0.9 (0.5-1.7)
|
| |
8.8-14.9
|
90 (51)
|
1.0 (ref.)
|
98 (42)
|
0.8 (0.7-1.0)
|
57 (23)
|
0.5 (0.3-0.6)
|
| |
≥15.0
|
70 (40)
|
1.0 (ref.)
|
103 (44)
|
1.1 (0.9-1.4)
|
153 (61)
|
1.6 (1.3-1.9)
|
- LRTI, lower respiratory tract infection; PR, prevalence ratio; CI, confidence interval; ref, reference; NA, not applicable; MAP, Mean Arterial Pressure; CURB65, Confusion Urea Respiration-frequency Blood-pressure 65years; PITT , Pitt’s bacteraemia severity score; CRP, C-reactive protein.
-
a In the n (%) columns data are either n (% of everyone we have data for) or median (interquartile range).
-
b Community acquired infections are defined as having the index date ≤ 2 days form admission.
-
c Mixed aetiology is defined as finding of other pathogenic bacteria than pneumococci in either blood or LRT specimen.
-
d Respiratory symptoms include dyspnoea, cough, sputum production and chest pain.
- Results were available for >87% of the patients except the individual measures that constitute the CURB65 score (58-99% worst for respiratory frequency and carbamide). CURB65 and PITT were calculated out of everyone, though at least one measure pr. patient was missing in 60-62% of patients for the CURB65 score and 9-18% for the PITT score. Missing valuables were regarded as “no”. Sums were thus calculated as “minimums”.
