Table 1 Management of patients with severe CAP
Historical | Intervention | ||
|---|---|---|---|
Group | Group | p | |
n=142 (44.8) | n=175 (55.2) | ||
Patients characteristics | |||
Age, yrs | 65.7 ± 14.4 | 64.2 ± 15.7 | 0.39 |
Male, n (%) | 109 (75.7) | 114 (65.1) | 0.02 |
Alcoholism, n (%) | 39 (27.4) | 48 (27.4) | 0.99 |
COPD, n (%) | 69 (48.6) | 63 (36) | 0.02 |
Chronic cardiac failure, n (%) | 19 (13.4) | 27 (15.4) | 0.60 |
Diabetes mellitus, n (%) | 15 (10.6) | 28 (16) | 0.15 |
Cancer, n (%) | 4 (2.8) | 14 (8) | 0.04 |
Immunosuppression, n (%) | 8 (5.6) | 34 (19.4) | 0.0003 |
Knaus score, n (%) | 0.18 | ||
A | 11 (7.7) | 21 (12) | |
B | 45 (31.7) | 69 (39.4) | |
C | 74 (52.1) | 72 (41.4) | |
D | 12 (8.4) | 13 (7.3) | |
ICU admission | |||
Within 24 hrs of hospital admission, n (%) | 112 (78.9) | 127 (72.6) | 0.19 |
SAPS II | 47.8 ± 16.3 | 48.7 ± 19.7 | 0.67 |
SOFA score | 6.2 ± 2.8 | 7.2 ± 3.7 | 0.008 |
PSI risk class V, n (%) | 93 (65.5) | 118 (67.4) | 0.71 |
Leukopenia, n (%) | 17 (12) | 13 (7.4) | 0.16 |
Hemoglobin level (g/dL) | 12.7 ± 2.5 | 11.8 ± 2.3 | 0.001 |
PaO2:FIO2 < 200 in patients with MV, n (%) | 84 (78.5) | 85 (66.4) | 0.04 |
Documented pneumonia, n (%) | 86 (60.6) | 100 (57.1) | 0.53 |
Pathogens* | |||
Streptococcus pneumoniae, n (%) | 45 (52.3) | 63 (63) | 0.42 |
Streptococcus pneumoniae with DSP, n (%) | 18 (20.9) | 17 (17) | 0.40 |
Staphylococcus aureus, n (%) | 12 (13.9) | 5 (5) | 0.02 |
Enterobacteriacea, n (%) | 11 ( 12.8) | 12 (12) | 0.76 |
Haemophilus Influenzae, n (%) | 12 (13.9) | 11 (11) | 0.45 |
Pseudomonas aeruginosa, n (%) | 4 (4.6) | 2 (2) | 0.29 |
Legionella pneumophila, n (%) | 1 (1.1) | 7 (7) | 0.06 |
Other, n (%) | 6 (6.9) | 7 (7) | 0.91 |
Bacteremia, n (%) | 19 (13.6) | 34 (19.4) | 0.16 |