Exclusion criteria | |
---|---|
(1) | Fulfilling criteria for chronic Q fever* |
(2) | Acute Q fever in the setting of a prosthetic cardiac valve or aneurysm surgery or stenting, necessitating prophylactic use of doxycycline |
(3) | Pregnancy or unwillingness to use effective contraceptives during the entire study period |
(4) | Imminent death |
(5) | Inability to give informed consent |
(6) | Allergy or intolerance to doxycycline |
(7) | Somatic or psychiatric illness that could explain the chronic fatigue |
(8) | Subjects who are currently enrolled in other investigational drug trials or receiving investigational agents |
(9) | Receiving or having received antibiotics for > 4 weeks, potentially active against Coxiella burnetii, for any other reason since Q fever diagnosis |
(10) | Subjects who are receiving and cannot discontinue barbiturates, phenytoin, or carbamazepine** |
(11) | Moderate or severe liver disease (AF, ALT, AST > 3 times the upper limit of normal) |
(12) | Current engagement in a legal procedure concerning financial benefits# |