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Table 2 All possible combinations of the six clinical and laboratory variables, along with the respective linear correlation coefficient (R 2 ) and its significance (P value), when correlated with CDI cure for patients in the 003 trial database with available values for all analyzed variables; n=515

From: Derivation and validation of a simple clinical bedside score (ATLAS) for Clostridium difficile infection which predicts response to therapy

 

R2

P value

 

R2

P value

Single variables

  

Four variables

  

Ag

0.91

0.195

Ag, Tr, Te, S *

0.92

<0.001

Tr

1.0

N/A

Ag, Tr, Te, Al

0.79

0.001

Te

0.95

0.147

Ag, Tr, Te, L

0.89

<0.001

L

1.0

0.025

Ag, Tr, Al, S

0.82

<0.001

Al

0.99

0.070

Ag, Tr, L, S

0.25

0.175

S

0.47

0.518

Ag, Tr, L, Al

0.75

0.001

   

Ag, Te, Al, S *

0.95

<0.001

Two variables

  

Ag, Te, L, S

0.78

0.008

Ag, Tr

0.78

0.048

Ag, Te, L, Al *

0.91

<0.001

Ag, Te

0.84

0.011

Ag, L, Al, S

0.87

0.001

Ag, S

0.49

0.191

Tr, Te, Al, S

0.79

0.001

Ag, Al *

0.97

0.003

Tr, Te, L, S

0.82

0.001

Ag, L

0.68

0.087

Tr, Te, L, Al

0.86

0.003

Tr, Te

0.79

0.044

Tr, L, Al, S

0.65

0.016

Tr, S

0.70

0.077

Te, L, Al, S *

0.91

<0.001

Tr, Al

0.84

0.030

   

Tr, L

0.26

0.375

Five variables

  

Te, S

0.06

0.702

Ag, Tr, Te, Al, S

0.80

<0.001

Te, Al *

0.92

0.002

Ag, Tr, Te, L, S

0.82

0.002

Te, L

0.89

0.058

Ag, Tr, S, L, Al **

0.95

<0.001

Al, S

0.90

0.015

Ag, Te, L, Al, S

0.78

0.001

L, S

0.63

0.108

Ag, Tr, Te, L, Al

0.86

<0.001

L, Al *

0.94

0.006

Tr, Te, L, Al, S

0.79

0.001

Three variables

  

Six variables

  

Ag, Tr, Te

0.85

0.003

Ag, Tr, Te, L, Al, S

0.70

0.001

Ag, Tr, S

0.86

0.003

   

Ag, Tr, Al

0.86

0.003

   

Ag, Tr, L *

0.96

<0.001

   

Ag, Te, S *

0.98

0.001

   

Ag, Te, Al

0.83

0.002

   

Ag, Te, L *

0.90

0.001

   

Ag, Al, S

0.86

0.002

   

Ag, L, S

0.10

0.482

   

Ag, L, Al

0.810

0.002

   

Tr, Te, S

0.82

0.005

   

Tr, Te, Al;

0.82

0.002

   

Tr, Te, L

0.71

0.036

   

Tr, Al, S

0.84

0.004

   

Tr, L, S

0.00

0.975

   

Tr, L, Al

0.49

0.081

   

Te, Al, S

0.17

0.366

   

Te, L, S

0.84

0.029

   

Te, L, Al *

0.95

<0.001

   

L, Al, S

0.79

0.003

   
  1. All combinations meeting the pre-set “acceptable” criteria (R2 ≥ 0.9 and P ≤ 0.01) are marked with an asterisk (*), and the single combination among this latter group which was composed of the largest number of variables is marked with a double asterisk (**) as the optimal scoring system.
  2. Ag = age; Tr = treatment with systemic antibiotics; Te = temperature; L = leukocyte count (total); Al = serum albumin; S = serum creatinine as a measure of renal function.
  3. CDI: Clostridium difficile infection.
  4. N/A: not applicable.