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Table 3 Summary of the number and rates of children with candidiasis per 1,000 children with hospital admission/year in HIV-infected children and HIV-uninfected children by calendar periods

From: Rate of candidiasis among HIV-infected children in Spain in the era of highly active antiretroviral therapy (1997–2008)

 

1997-1999

2000-2002

2003-2008

Description

No.

Rate (95% CI)

No.

Rate (95% CI)

No.

Rate (95% CI)

All candidiasis

      

   HIV-uninfected children

8

6.1 (1.9; 10.3)

4

3.1 (0.1; 6.1)

14

10.7 (5.1; 16.3)

   HIV-infected children

64

150.0 (106.4; 175.5)

41

90.3 (62.7; 117.9)

36

79.3 (53.4; 105.2)

   p-value

 

<0.001

 

<0.001

 

<0.001

Non-invasive Candida mycosis (Non-ICM)

      

   HIV-uninfected children

5

3.8 (0.5; 7.1)

3

2.3 (0; 4.8)

8

6.0 (1.8; 10.2)

   HIV-infected children

50

118.5 (85.6; 151.3)

36

85.3 (57.4; 113.2)

34

80.6 (53.5; 107.6)

   p-value

 

<0.001

 

<0.001

 

<0.001

Invasive Candida mycosis (ICM)

      

   HIV-uninfected children

3

1.2 (0; 2.5)

1

0.4 (0; 1.1)

6

2.3 (0.5; 4.2)

   HIV-infected children

14

32.4 (15.4; 49.4)

5

11.6 (1.4; 21.7)

2

4.6 (0; 11.1)

   p-value

 

<0.001

 

<0.001

 

0.387

  1. Abbreviations: ICM, invasive candidiasis mycosis; HIV, Human immunodeficiency virus; Rate, events per 1,000 children with hospital admission/yea; 95% CI, 95% of confidence interval.
  2. Statistically significant differences are shown in bold.