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Efficacy of anti-diarrheal activity of Pedalium murex L., in wistar albino rats
© Ravikumar et al; licensee BioMed Central Ltd. 2012
Published: 4 May 2012
Diarrhea is a major health problem especially for children under the age of 5 and up to 17% of children admitted in the pediatric ward die of diarrhea. A range of medicinal plants with anti-diarrheal properties is widely used by traditional healers.
The ethyl acetate extract of Pedalium murex L., (250, 500, and 1000 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea model in rat. Two other groups received normal saline (5mg/kg) and loperamide (5mg/kg) as positive control. The effect of the extract on intestinal transit and castor oil-induced intestinal fluid accumulation (enteropooling) was assessed.
At oral doses of 250, 500, and 1000 mg/kg body weight, the plant extract showed pronounced and dose-dependent anti-diarrheal activity. The protective role of the extract at 1000 mg/kg was comparable to that of the reference drug, loperamide (5mg/kg). The extract (1000 mg/kg) produced a decrease in intestinal transit comparable to atropine (5mg/kg), and significantly (p<0.01) inhibited castor oil-induced enteropooling. No mortality and visible signs of general weakness were observed in the rats following the extract administration of up to a dose of 6000 mg/kg.
The results showed that the extract of Pedalium murex L., has a significant anti-diarrheal activity which supports its use in traditional herbal medicine practice.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.