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Efficacy of anti-diarrheal activity of Pedalium murex L., in wistar albino rats

Background

Diarrhea is a major health problem especially for children under the age of 5 and up to 17% of children admitted in the pediatric ward die of diarrhea. A range of medicinal plants with anti-diarrheal properties is widely used by traditional healers.

Methods

The ethyl acetate extract of Pedalium murex L., (250, 500, and 1000 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea model in rat. Two other groups received normal saline (5mg/kg) and loperamide (5mg/kg) as positive control. The effect of the extract on intestinal transit and castor oil-induced intestinal fluid accumulation (enteropooling) was assessed.

Results

At oral doses of 250, 500, and 1000 mg/kg body weight, the plant extract showed pronounced and dose-dependent anti-diarrheal activity. The protective role of the extract at 1000 mg/kg was comparable to that of the reference drug, loperamide (5mg/kg). The extract (1000 mg/kg) produced a decrease in intestinal transit comparable to atropine (5mg/kg), and significantly (p<0.01) inhibited castor oil-induced enteropooling. No mortality and visible signs of general weakness were observed in the rats following the extract administration of up to a dose of 6000 mg/kg.

Conclusion

The results showed that the extract of Pedalium murex L., has a significant anti-diarrheal activity which supports its use in traditional herbal medicine practice.

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Correspondence to R Ravikumar.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ravikumar, R., Baskar, A., Nithya, V. et al. Efficacy of anti-diarrheal activity of Pedalium murex L., in wistar albino rats. BMC Infect Dis 12, P90 (2012). https://doi.org/10.1186/1471-2334-12-S1-P90

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Keywords

  • Diarrhea
  • Traditional Healer
  • Ethyl Acetate Extract
  • Loperamide
  • Major Health Problem