- Poster presentation
- Open access
- Published:
Correlation between oxidative stress indices and CD4 counts in HIV infected patients
BMC Infectious Diseases volume 12, Article number: P71 (2012)
Background
HIV infection induces wide array of immunologic alterations resulting in progressive development of AIDS. Of the mechanisms contributing to this progression, oxidative stress induced by the production of reactive oxygen species may play a critical role in the stimulation of HIV replication and development of immunodeficiency. This study was conducted to measure total antioxidant capacity and lipid peroxidation in HIV patients and correlate with their CD4 counts.
Methods
The present cross-sectional study comprised of 4 groups. Group-1: Normal controls (n=100), Group-2: HIV patients with CD4 count > 500 cells/micro liter (n=100), Group-3: HIV patients with CD4 count between 200-499 cells/micro liter (n=100) and Group-4: HIV patients with CD4 count < 200 cells/micro liter (n=100). The CD4 counts were performed by Tricolor Flowcytometer. Evaluation of lipid peroxidation was performed by estimating serum malondialdehyde, while the marker for total antioxidant capacity was performed by FRAP assay. The oxidative stress index was measured. The statistical significance was determined by unpaired Student’s t-test and Pearson’s correlation coefficient at 5% level significance.
Results
There was statistically significant negative correlation found between CD4 counts and MDA [p value <0.001] and significant positive correlation was found between CD4 counts and TAC in HIV-infected patients [p value <0.001].
Conclusion
The oxidative stress markers were inversely proportional to CD4 counts in HIV patients reflecting the increased formation of ROS and lipid peroxidation with progressive immunodeficiency. The TAC levels were directly proportional to CD4 counts. Thus, antioxidant therapy can be useful to monitor and optimize the management of HIV-infected patients.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Annam, V., Suresh, D. Correlation between oxidative stress indices and CD4 counts in HIV infected patients. BMC Infect Dis 12 (Suppl 1), P71 (2012). https://doi.org/10.1186/1471-2334-12-S1-P71
Published:
DOI: https://doi.org/10.1186/1471-2334-12-S1-P71