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  • Open Access

A comparative study of Pap smear findings among HIV positive and negative women at Government Hospital of Thoracic Medicine (GHTM), Tambaram

  • 1Email author,
  • 2,
  • 3,
  • 2,
  • 2 and
  • 1
BMC Infectious Diseases201212 (Suppl 1) :P35

  • Published:


  • Cervical Cancer
  • Cervical Intraepithelial Neoplasia
  • Intraepithelial Neoplasia
  • Indian Woman
  • Government Hospital


Cancer cervix is a major health problem in India, accounting for 26.1-43.8% of all cancers in Indian women. Dysplasia on Pap smear has been reported in 15-40% of HIV positive women which is 10-11 times higher than those observed among HIV negative women. Patients with persistent inflammatory Pap smears harbor high proportion of HPV infection and cervical intraepithelial neoplasia (20.9%). The purpose of this present study was to compare Pap smear findings in HIV-infected and uninfected women at GHTM and to correlate the Pap smear abnormalities among HIV positive women with their immune status.


All women (18-45 years of age), admitted at GHTM, between July-Sept. 2010, consented were selected and Pap smear was performed. Smears were reported by a pathologist blinded to the HIV status of patients. Results were analyzed by using PASW 18 version.


Total 300 samples were collected in which 204 were HIV positive and 96 were HIV negative. HIV positive women (58.8%) had more Pap smear abnormalities such as cervical dysplasia (3.92%), inflammatory smear (51.96%), infection (2.94%) (p=0.010) when compared with HIV negative women (43.75). Among HIV positives 63.93% had CD4 count less than 250 (p=0.048), and 64.3% had coexisting opportunistic infection (p=0.04). On speculum examination, cervicitis was present in 63.3% of HIV positive women with abnormal pap smears (p=0.004).


This study showed a high percentage of inflammatory Pap smears (51.96%) among HIV positives. Hence these patients will require a follow up Pap smear and colposcopy and biopsy if inflammation is persistent to exclude cervical cancer.

Authors’ Affiliations

Government Hospital of Thoracic Medicine (GHTM), Tambaram, Chennai, Tamil Nadu, India
International Training and Education Centre on Health (I-TECH India/AroGyaan), Chennai, Tamil Nadu, India
Arignar Anna Memorial Cancer Institute and Hospital, Kanchipuram, Tamil Nadu, India


© Seethalakshmi et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.