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Table 2 History of acute respiratory illness, including influenza-like illness (ILI), and laboratory evidence of 2009 pandemic influenza A (H1N1) infections in 60 vaccinated with a monovalent 2009 pandemic influenza A(H1N1) vaccine and 90 unvaccinated healthcare workers at a children's hospital during and after 2009 acute H1N1 influenza pandemic in Taiwan

From: Longitudinal seroepidemiologic study of the 2009 pandemic influenza A (H1N1) infection among health care workers in a children's hospital

  All
(N = 150)
Vaccinated Unvaccinated  
   All (N = 60)
No. (%)
High risk1 (N = 53)
No. (%)
Low risk1 (N = 7)
No. (%)
P value2 All (N = 90)
No. (%)
High risk1 (N = 40)
No. (%)
Low risk1 (N = 50)
No. (%)
P value2
Age, mean ± SD [range], year 31.8 ± 6.3[22-59] 31.7 ± 5.8[24-59] 31.8 ± 5.8[27-59] 31.1 ± 6.2[24-42] 0.534 31.8 ± 6.7[23-58] 29.5 ± 5.5[23-58] 33.9 ± 6.9[23-51] < 0.001
Male: Female 34:116 16:44 16:37 0:7 0.173 18:72 12:28 6:44 0.061
History of respiratory illness          
Before 1st serum          
Acute respiratory illness 23 (15.3%) 16 (26.7%) 11 (20.8%) 5 (71.4%) 0.012 7 (7.8%) 3 (7.5%) 4 (8.0%) 1
ILI episodes 9 (6.0%) 5 (8.3%) 3 (5.7%) 2 (28.6%) 0.100 4 (4.4%) 2 (5.0%) 2 (4.0%) 1
2009 H1N1 infection3 0(0%) 0(0%) 0(0%) 0(0%) NA 0 (0%) 0 (0%) 0 (0%) NA
Between 1st & 2nd sera          
Acute respiratory illness 54 (36%) 21 (35.0%) 18 (34.0%) 3 (42.9%) 0.687 33 (36.7%) 15 (37.5%) 18 (36.0%) 1
ILI episode 13 (8.7%) 5 (8.3%) 5 (9.4%) 0(0%) 1 8 (8.9%) 6 (15.0%) 2 (4.0%) 0.132
2009 H1N1 infection3 8 (5.3%) 1 (1.7%) 1 (1.9%) 0(0%) 1 7 (7.8%) 5 (12.5%) 2 (4.0%) 0.235
Virologically confirmed4 5 (3.3%) 1 (1.7%) 1 (1.9%) 0(%)) 1 4 (4.4%) 3 (7.5%) 1 (2.0%) 0.319
With serological evidence5 6 (4.0%) 0(0%) 0(0%) 0(0%) 1 6 (6.7%) 5 (12.5%) 1 (2.0%) 0.085
Between 2nd & 3rd sera          
Acute respiratory illness 57 (38%) 24 (40.0%) 21 (39.6%) 3 (42.9%) 1 33 (36.7%) 15 (37.5%) 18 (36.0%) 1
ILI episodes 23 (15.3%) 10 (16.6%) 9 (17.0%) 1 (14.3%) 1 13 (14.4%) 7 (17.5%) 6 (12.0%) 0.552
2009 H1N1 infection3 10 (6.7%) 2 (3.3%) 2 (3.8%) 0 (0%) 1 8 (8.9%) 5 (12.5%) 3 (6.0%) 0.458
Virologically confirmed4 6 (4.0%) 2 (3.3%) 2 (3.8%) 0 (0%) 1 4 (4.4%) 2 (5.0%) 2 (4.0%) 1
With serological evidence5 7 (4.7%) NA NA NA NA 7 (7.8%) 4 (10.0%) 3 (6.0%) 0.695
  1. Abbreviations: NA, not applicable; SD, standard deviation; ILI, influenza-like illness
  2. 1 See text for definition of high- and low-risk groups
  3. 2 P values were calculated by Chi-square test or Fisher exact test to compare high- and low-risk groups.
  4. 3 2009 H1N1 infection means subjects with laboratory evidence, either positive viral isolation, positive real time polymerase chain reaction, or seroconversion, of 2009 pandemic influenza A (H1N1) infection.
  5. 4 Virologically confirmed means either viral isolation or real-time polymerase chain reaction was positive of 2009 pandemic influenza (H1N1) virus.
  6. 5 With serological evidence with seroconversion or four fold rise of antibodies against 2009 pandemic influenza (H1N1) virus.