Table 2 Diagnostic performance of Inno-Lia algorithms for recent HIV-1 infection among the 1267 patients with incident or older infection of Table 1
From: Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection
Alg # | Definition | Sensitivity % | Specificity % | Overall correct % (rank) | LLR Chi-square (rank) | Rank sum (final rank) |
|---|---|---|---|---|---|---|
15.1 | if (sgp120 ≤ 1 AND p31 ≤ 1 AND p17 ≤ p24) OR (gp41 ≤ 2 AND p31 ≤ 1 AND p17 ≤ p24) OR (p17 ≥ 2 AND p31 = 0 AND p17 ≤ p24) OR (p31 = 0 AND p24 ≥ 2 AND p17 ≤ p24) then RECENT else older | 61.67 | 95.14 | 81.22 (1) | 524.69 (2) | 3 (1) |
15 | if (sgp120 ≤ 1 AND p31 ≤ 1) OR (gp41 ≤ 2 AND p31 ≤ 1) OR (p17 ≥ 2 AND p31 = 0) OR (p31 = 0 AND p24 ≥ 2) then RECENT else older | 62.24 | 94.32 | 80.98 (2) | 509.19 (4) | 6 (2) |
11.2 | if (sgp120+gp41 ≤ 2.5) OR ((sgp120+gp41+p31+p24+p17 ≤ 6.5) AND p31 ≤ 1 AND p17 ≤ p24) OR (p31 = 0 AND p24 ≥ 2) then RECENT else older | 61.48 | 94.05 | 80.51 (3) | 490.62 (6) | 9 (3.5) |
13 | if (sgp120+gp41 ≤ 4 AND p31 = 0) OR (p31 = 0 AND p24 ≥ 2) then RECENT else older | 59.77 | 95.00 | 80.35 (4) | 493.18 (5) | 9 (3.5) |
7 | if sgp120+gp41+p31 ≤ 4 then RECENT else older | 54.08 | 98.38 | 79.95 (10.5) | 530.11 (1) | 11.5 (5) |
9 | if sgp120+gp41 ≤ 4 AND p31 = 0 then RECENT else older | 52.75 | 98.38 | 79.40 (12) | 511.40 (3) | 15 (6) |
11.1 | if (sgp120+gp41 ≤ 2.5) OR ((sgp120+gp41+p31+p24+p17 ≤ 6.5) AND p31 ≤ 1 OR (p31 = 0 AND p24 ≥ 2) then RECENT else older | 61.48 | 93.51 | 80.19 (6.5) | 475.99 (9) | 15.5 (7) |
12.1 | if (p24 ≥ 2 AND p31 = 0) OR (gp41 ≤ .5) OR (sgp120+gp41+p31 ≤ 4) OR (p31 ≤ 1 AND (sgp120+gp41+p31+p24+p17 ≤ 6.5)) then RECENT else older | 61.67 | 93.38 | 80.19 (6.5) | 475.12 (10) | 16.5 (8) |
4.1 | if p31 ≤ 0.5 then RECENT else older | 63.95 | 91.89 | 80.27 (5) | 470.01 (14) | 19 (9.5) |
12 | if (p24 ≥ 2 AND p31 = 0) OR (gp41 ≤ .5) OR (sgp120+gp41+p31 ≤ 4 OR sgp120+gp41+p31+p24+p17 ≤ 6.5) then RECENT else older | 61.67 | 93.37 | 80.17 (8) | 474.55 (11) | 19 (9.5) |
8.1 | if gp41 ≤ 0.5 OR (sgp120+gp41+p31 ≤ 4) OR ((sgp120+gp41+p31+p24+p17 ≤ 6.5) AND p31 ≤ 1) then RECENT else older | 54.65 | 96.76 | 79.24 (13) | 476.63 (7) | 20 (11) |
11 | if (sgp120+gp41 ≤ 2.5) OR (sgp120+gp41+p31+p24+p17 ≤ 6.5) OR (p31 = 0 AND p24 ≥ 2) then RECENT else older | 61.48 | 93.37 | 80.09 (9) | 471.87 (12) | 21 (12) |
8 | if gp41 ≤ 0.5 OR (sgp120+gp41+p31 ≤ 4) OR (sgp120+gp41+p31+p24+p17 ≤ 6.5) then RECENT else older | 54.65 | 96.75 | 79.23 (14) | 476.13 (8) | 22 (13) |
13.1 | if gp41 ≤ 2 OR (p31 = 0 AND p24 ≥ 2) then recent else older | 60.34 | 93.92 | 79.95 (10.5) | 470.77 (13) | 23.5 (14) |
3 | if gp41 ≤ 0.5 then RECENT else older | 20.30 | 100.0 | 66.85 (25) | 201.79 (23) | 24.5 (22) |
4 | if p31 = 0 then RECENT else older | 60.15 | 92.70 | 79.16 (15) | 436.83 (16) | 31 (15) |
17 | if (sgp120 * gp41) ≤ 2 then RECENT else older | 50.09 | 98.24 | 78.22 (17) | 469.33 (15) | 32 (16) |
2 | if sgp120 ≤ 1 then RECENT else older | 54.46 | 95.41 | 78.37 (16) | 431.97 (17) | 33 (17) |
16 | if (sgp120 ≤ 1 AND (p31+p24+p17 ≤ 2.5)) OR (gp41 ≤ 1) OR (p31 ≤ 0.5 AND (sgp120+gp41+p24+p17 ≥ 15)) OR (p24 = 0 AND gp41 ≤ 2) OR (p24 ≥ 3 AND p31 = 0) then RECENT else older | 50.47 | 96.62 | 77.43 (18) | 416.47 (19) | 37 (18.5) |
18 | if (sgp120 * gp41 ≤ 1) OR (p24+p31 = 0) then RECENT else older | 46.11 | 98.24 | 76.56 (19) | 416.96 (18) | 37 (18.5) |
14 | if (sgp120+gp41+p31+p24+p17 ≤ 6.5 AND p31 ≤ 1) then RECENT else older | 45.92 | 97.84 | 76.24 (20) | 399.26 (20) | 40 (20) |
3.2 | if gp41 ≤ 2 then RECENT else older | 44.02 | 98.11 | 75.61 (21) | 385.38 (21) | 42 (21) |
6 | if p17 = 0 then RECENT else older | 40.80 | 90.80 | 69.98 (22) | 178.75 (24) | 46 (22.5) |
3.1 | if gp41 ≤ 1 then RECENT else older | 23.53 | 100.0 | 68.19 (24) | 236.77 (22) | 46 (22.5) |
10 | if p31 = 0 AND p24 ≥ 2 then RECENT else older | 30.93 | 95.27 | 68.51 (23) | 164.49 (25) | 48 (24.5) |
5 | if p24 ≤ 0 then RECENT else older | 26.00 | 95.54 | 66.61 (26) | 125.29 (26) | 52 (26) |