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Table 1 Clinical score parameters, assessed values and weighted scores

From: Characterization of a pneumococcal meningitis mouse model

Parameter

Value

Weighted score

Maximum score

Weight loss from baseline

5%

0

 
 

10%

1

 
 

15%

2

 
 

20%

3

 
 

25%

4

4

Activity

normal

0

 
 

increased/decreased

1

 
 

mildely deminished

1

 
 

deminished

2

 
 

severely deminished

3

 
 

coma

4

4

Time to return to upright

normal

0

 

position

upright < 5 sec

2

 
 

upright < 30 sec

4

 
 

no turn upright

6

6

Coat

normal

0

 
 

deminished grooming

1

 
 

soiled

1

 
 

piloerection

1

3

Posture

normal

0

 
 

sligh hunched back

1

 
 

sev hunched back

2

2

Eyes

normal

0

 
 

protruding

1

 
 

sunken eyes

1

 
 

closed eyelids

1

 
 

discharge

1

4

Respiration rate (per min)

> 150

0

 
 

< 150

1

 
 

< 100

2

 
 

< 75

3

 
 

< 50

4

4

Breathing

irregular

2

 
 

laboured

2

4

Neurologic exam

normal

0

 
 

ataxia

2

 
 

limb paresis/paralysis

2

 
 

epileptic seizure

2

 
 

status epilepticus

6

10

Total

  

41

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BMC Infectious Diseases

ISSN: 1471-2334

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