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Table 1 Clinical score parameters, assessed values and weighted scores

From: Characterization of a pneumococcal meningitis mouse model

Parameter Value Weighted score Maximum score
Weight loss from baseline 5% 0  
  10% 1  
  15% 2  
  20% 3  
  25% 4 4
Activity normal 0  
  increased/decreased 1  
  mildely deminished 1  
  deminished 2  
  severely deminished 3  
  coma 4 4
Time to return to upright normal 0  
position upright < 5 sec 2  
  upright < 30 sec 4  
  no turn upright 6 6
Coat normal 0  
  deminished grooming 1  
  soiled 1  
  piloerection 1 3
Posture normal 0  
  sligh hunched back 1  
  sev hunched back 2 2
Eyes normal 0  
  protruding 1  
  sunken eyes 1  
  closed eyelids 1  
  discharge 1 4
Respiration rate (per min) > 150 0  
  < 150 1  
  < 100 2  
  < 75 3  
  < 50 4 4
Breathing irregular 2  
  laboured 2 4
Neurologic exam normal 0  
  ataxia 2  
  limb paresis/paralysis 2  
  epileptic seizure 2  
  status epilepticus 6 10
Total    41