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Table 2 Characteristics of HSCT patients with and without invasive fungal infections

From: Invasive fungal infection among hematopoietic stem cell transplantation patients with mechanical ventilation in the intensive care unit

  Invasive fungal infection
(n = 20)
Without invasive fungal infection
(n = 40)
P-value
Median age at ICU admission 30 ± 7.9 37 ± 11.0 0.024 *
Gender
   Male 12 (60%) 15 (37.5%) 0.099  
   Female 8 (40%) 25 (62.5%)   
Early vs. late ICU admission after HSCT (day) 209 ± 158.2 73 ± 56.6 0.068  
ICU length of stay (day) 10.7 ± 7.6 12.8 ± 14.5 0.533  
Underlying disease
   ALL 4 (20%) 5 (12.5%)   
   AML 8 (40%) 7 (17.5%)   
   CML 3 (15%) 9 (22.5%)   
   Multiple myeloma 1 (5%) 3 (7.5%)   
   Hodgkin's disease 2 (10%) 2 (5%)   
   Other hematological disease 2 (10%) 14 (34.5%)   
Type of transplantation
   Allo-PBSCT/Allo-BMT 13 (65%)/4 (20%) 24 (60%)/5 (12.5%)   
   Auto-PBSCT/Auto-BMT 3 (15%)/0 10 (25%)/1 (2.5%)   
GVHD 16 (80%) 15 (37.5%) 0.003 **
CMV infection 7 (35%) 6 (15%) 0.101  
Neutropenia 16(80%) 32 (80%) 0.099  
Concurrent bacteremia 12 (60%) 26 (65%) 0.705  
High dose corticosteroid 13 (65%) 10 (25%) 0.003 *
APACHE II score 22 ± 5.7 27 ± 9.8 0.014 *
SOFA score 10.45 ± 2.7 13 ± 4.0 0.020 *
ICU mortality 17 (85%) 36 (90%) 0.676  
  1. *: p < 0.05; **: p < 0.01.
  2. Data represent as mean ± S.D or number (percentage).
  3. Abbreviations: HSCT: hematopoietic stem cell transplantation; ALL: acute lymphoid leukemia; AML: acute myeloid leukemia; CML: chronic myeloid leukemia; MDS: myelodysplastic syndrome; PBSCT: peripheral blood stem cell transplantation; BMT: bone marrow transplantation; GVHD: graft versus host disease; APACHE II: acute physiology and chronic health evaluation II; SOFA score: sequential organ failure assessment score; and ICU: intensive care unit.