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Table 2 Susceptibility profiles of 48 RPKP and 36 RNKP isolates

From: Epidemic of Klebsiella pneumoniae ST11 Clone Coproducing KPC-2 and 16S rRNA Methylase RmtB in a Chinese University Hospital

Antimicrobial agents MIC range, μg/mL MIC 50, μg/mL MIC 90, μg/mL Susceptible percentage,% P-value
RNKP(n = 48) RPKP(n = 36) RNKP RPKP RNKP RPKP all isolates RNKP RPKP
Imipenem 4-256 8-128 128 128 256 128 0 0 0
Meropenem 2-256 4-128 64 64 128 64 0 0 0
Ertapenem 4-512 8-512 128 128 256 128 0 0 0
Cefotaxime 16 to >512 16 to >512 256 >512 512 >512 0 0 0
Cefepime 4-256 4-512 128 128 128 512 11.1 11.1 11.1 >0.99
Gentamicin 1 < to >512 256 to >512 8 >512 128 >512 21 47.2 0 <0.01
Netilmicin 1 to >512 256 to >512 8 >512 256 >512 32.1 72.2 0 <0.01
Amikacin 2 to >512 256 to >512 4 >512 >512 >512 39.5 88.9 0 <0.01
Tetracycline 4 to >512 8-256 16 32 512 128 3.7 8.3 0 0.084
Minocycline 2-128 4-32 4 8 64 32 27.2 52.8 6.7 <0.01
Ciprofloxacin 0.25 < to 64 2-64 64 64 64 64 6 13.9 0 0.015
Ofloxacin 0.25 < to 64 1-64 64 64 64 64 8.4 13.9 4.3 0.23
Tigecycline 0.5-4 0.5-4 2 2 2 2 96.3 97.2 95.6 >0.99
Colistin 0.25-256 0.5-2 1 1 2 2 98.8 97.2 100 0.44
Fosfomycin 1 to >1024 2 to > 1024 16 >1024 64 >1024 43.4 88.9 8.5 <0.01
  1. Footnotes. RPKP, rmtB-positive KPC-producing K. pneumoniae; RNKP, rmtB-negative KPC-producing K. pneumoniae; MIC, minimum inhibitory concentration; MIC50, MIC required to inhibit the growth of 50% of organisms; MIC90, MIC required to inhibit the growth of 90% of organisms.