Analysis of gene mutations associated with isoniazid, rifampicin and ethambutol resistance among Mycobacterium tuberculosisisolates from Ethiopia

Table 3 Performance of GenoType^® MTBDRplus assay for detection of resistance to INH, RMP and MDR and GenoType^® MTBDRsl assay for detection of EMB resistance in comparison to BacT/ALERT 3D system

Molecular methods DST results		BacT/ALERT 3D DST results		Sensitivity %	Specificity %	PPV %	NPV %
		Susceptible	Resistant
INH	Susceptible	222	3	91.7	99.1	94.3	98.7
	Resistant	2	33
RMP	Susceptible	245	0	100	100	100	100
	Resistant	0	15
INH +RMP (MDR)	Susceptible	247	0	100	100	100	100
	Resistant	0	13
EMB	Susceptible	241	11	42	100	100	95.6
	Resistant	0	8

DST drug susceptibility testing, INH isoniazid, RMP rifampicin, MDR multidrug resistance, EMB ethambutol, PPV positive predictive value, NPV negative predictive value

ISSN: 1471-2334