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Table 4 Summary of meta-analysis results in the achievement of the virological outcome by Pegylated interferon α-2a and α-2b plus ribavirin in patients with genotype 1 chronic hepatitis C

From: Efficacy of pegylated interferon α-2a and α-2b in patients with genotype 1 chronic hepatitis C: a meta-analysis

Outcomes

N° of studies

N° of patients

N° and (%) of events

RR (efficacy)

95% CI (efficacy)

p

Heterogeneity test

α-2a/α-2b

α-2a/α-2b

(Q;p;I2,%)

Rapid Virological Response

4 [1719, 22]

1,374/1,355

186(13.5)/174(12.8)

1.05

0.87–1.27

0.62

3.8;0.28;21.1

Early Virological Response

5[1719, 21, 22]

1,395/1,371

649(46.5)/572(38.4)

1.12

1.03–1.22

0.011

7.58;0.14;42.8

End of Treatment Response

5[16, 18, 19, 21, 22]

1,243/1,217

782(62.9)/627(51.5)

1.22

1.14–1.31

<0.0001

7.6;0.11;47.3

5*[16, 18, 19, 21, 22]

921/879

544(59)/403(45.8)

1.29

1.18–1.41

<0.0001

8.37;0.08;52.1

Sustained Virological Response

6[16, 1822]

1,336/1,310

574(43)/521(39.8)

1.08

0.99–1.18

0.098

9.97;0.08;49.8

6**[16, 1822]

1,058/732

473(44.7)/306(41.8)

1.08

0.97–1.20

0.19

10.9;0.053;54.2

6*[16, 1822]

1,014/972

406(40)/346(35.5)

1.13

1.01–1.26

0.04

8.59;0.13;41.8

  1. * In McHutchison’s study [19] only patients without ribavirin reduction were included.
  2. ** In McHutchison’s study [19] only patients with adequate ribavirin dosage (≥13 mg/kg/die) were included.