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Table 2 Univariate analysis of factors associated with HSE mortality and morbidity

From: Impact of Herpes simplex virus load and red blood cells in cerebrospinal fluid upon herpes simplex meningo-encephalitis outcome

Variables Mortality (n=43) Morbidity (n=39*)
  Alive (n=29) Dead (n=14) p Low (n=17) GOS 1-3 High (n=22) GOS 4-5 P
Median HSV load (Log10 copies/μL) 2.1 1.7 0.95 2.0 1.8 0.95
Age in years (median) 59 71 0.03 57 64 0.04
Knaus score (%)    0.07    0.004
Normal health status (A) 64.3 35.7   81,3 18.8  
Moderate limitation in bedridden patients (B-D) 35.7 64.3   33.3 66.7  
Lymphocytic CSF (%) 66.7 41.7 0.17 80.0 42.1 0.04
Median blood red cell counts in CSF (cells/μL) 4 49 0.17 0 49 0.05
Median time to lumbar puncture (days) 0 1 0.23 0 1 0.02
Median time to acyclovir initiation (days) 0 2 0.08 0 2 0.006
  1. * Morbidity analysis was performed for 38 patients, since Glasgow outcome scale was not available for five patients.
  2. GOS 1–3: Glasgow outcome scale, classes 1 to 3: good recovery to moderate disability.
  3. GOS 4–5: Glasgow outcome scale, classes 4 and 5: severe disability and death.