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Table 2 Characterization of the A 2A AR agonist, ATL370, by radioligand binding (mean ± SD)

From: Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficileinfection in mice following vancomycin treatment

Receptor

A1AR

A2AAR - higha

A2AAR- lowa

A2BAR

A3AR

Radioligand

125I-ABA

125I-APE

125I-ZM241385

125I-ABOPX

125I-ABA

Human (K i , nM)

61.1 ± 11.3

0.5 ± 0.2

3.8 ± 0.7

>10,000

130.4 ± 44.4

Mouse (K i , nM)

65.3 ± 15.8

N/A

4.3 ± 2.8

>10,000

84.2 ± 19.2

  1. aAgonists are known to bind to two affinity states of G-protein coupled receptors. Low affinity reflects binding to uncoupled receptors. High affinity refers to binding to receptor-G protein complexes.
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BMC Infectious Diseases

ISSN: 1471-2334

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