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Table 2 Characterization of the A 2A AR agonist, ATL370, by radioligand binding (mean ± SD)

From: Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficileinfection in mice following vancomycin treatment

Receptor A1AR A2AAR - higha A2AAR- lowa A2BAR A3AR
Radioligand 125I-ABA 125I-APE 125I-ZM241385 125I-ABOPX 125I-ABA
Human (K i , nM) 61.1 ± 11.3 0.5 ± 0.2 3.8 ± 0.7 >10,000 130.4 ± 44.4
Mouse (K i , nM) 65.3 ± 15.8 N/A 4.3 ± 2.8 >10,000 84.2 ± 19.2
  1. aAgonists are known to bind to two affinity states of G-protein coupled receptors. Low affinity reflects binding to uncoupled receptors. High affinity refers to binding to receptor-G protein complexes.