Figure 3
Effect of Timing of A 2A AR Agonist ATL370 Treatment on C.difficile-Infected Mice. Mice were infected with VPI10463 at 105 inoculum and treated or not with vancomycin (50 mg/kg/day for 3 days) with or without ATL370 (1 ng/kg/min started either at day 1 or day 4 after infection). A. Survival Curve, p=0.1427 by Mantel-Cox. B. Clinical Scores; **p<0.01 for I vs. I with Vanc, *p<0.05 to 0.01 for I vs. I with Vanc plus ATL370 by Two-way ANOVA.