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Table 4 Genetic frequency of the genotypes of eight SNPs in six genes and their association with infection by influenza A/H1N1 virus

From: Pandemic influenza A/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCLpolymorphisms in Mexican population: a case–control study

Gene and genotype

Genetic frequency

 

A/H1N1 group

AHC group

p

OR

95% CI

ILI group

p

OR

95% CI

CCL1 rs2282691

         

AA

0.643

0.402

0.0085

2.67

1.26-5.81

0.630

0.0096

2.53

1.23-5.30

TA

0.286

0.456

   

0.304

   

TT

0.071

0.142

   

0.065

   

IL1B rs16944

         

GA

0.535

0.449

   

0.583

   

GG

0.442

0.364

   

0.375

   

AA

0.023

0.188

0.015

0.10

0.00-0.66

0.042

0.024

0.19

0.02-0.79

IL8 rs4073

         

AT

0.659

0.445

0.0231

2.40

1.12-5.32

0.500

   

AA

0.244

0.396

   

0.386

   

TT

0.098

0.159

   

0.114

   

IL6 rs1818879

         

GG

0.439

0.268

   

0.381

   

AG

0.390

0.530

   

0.452

   

AA

0.171

0.202

   

0.167

   

LTA rs909253

         

CT

0.535

0.244

0.0004

3.56

1.68-7.54

0.540

0.00014

3.63

1.79-7.38

TT

0.302

0.488

0.0432

0.45

0.20-0.97

0.320

0.0517*

0.49

0.24-1.00

CC

0.163

0.267

   

0.140

   

TNF

         

  rs361525

         

GG

0.818

0.884

   

0.894

   

AA

0.136

0.006

0.00031

27.0

3.07-1248.77

0.000

   

GA

0.045

0.110

   

0.106

   

  rs1800629

         

GG

0.932

0.946

   

0.911

   

GA

0.068

0.054

   

0.089

   

AA

0.000

0.000

       

  rs1800750

         

GG

0.789

0.949

0.0035

0.20

0.06-0.66

0.830

0.0116

0.26

0.08-0.84

AA

0.158

0.028

0.005

6.41

1.51-27.92

0.128

0.0128

5.00

1.20-21.61

GA

0.053

0.023

   

0.043

   
  1. A/H1N1 group: patient infected with influenza A/H1N1 virus; AHC group: asymptomatic, healthy contacts; ILI group: patients with influenze-like illness; OR: odds ratio; CI: confidence interval. Results were considered statistically significant when p was <0.05.
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BMC Infectious Diseases

ISSN: 1471-2334

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