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Table 4 Univariate and multivariate regression analysis of the association of factors with death among pregnant women with confirmed pH1N1 influenza*

From: Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China

Variables Patients who survived (n = 317) Patients who died (n = 77) Pvalue ORuadj (95% CI) ORadj (95% CI)
Age, median years (IQR) 24.8 (22.9-28.3) 23.9 (21.7-28.3) 0.10 0.95 (0.90-1.01)  
BMI, median (IQR) 25.99 (23.20-29.26) 27.37 (24.87-30.33) 0.02 1.10 (1.01-1.17) 1.26 (1.09-1.47)
Gestational age, median (IQR) 32 (26-37) 32 (26-38) 0.86 0.97 (0.97-1.03) 0.94 (0.86-1.03)
Comorbidity **(%) 25/317 (7.9) 6/77 (7.8) 0.97 0.98 (0.39-2.50)  
Pneumonia (%) 275/311 (88.4) 75/77 (97.4) 0.03 4.91 (1.16-20.86) 0.68(0.02-2.39)
Symptoms and Lab findings      
PaO2/FiO2, median (IQR)      
PaO2/FiO2 ≥ 300 (%) 62/164 (37.8) 1/55 (1.8)   Referent Referent
PaO2/FiO2 201 to 300 (%) 23/164 (14.0) 2/55 (3.6) 0.18 5.39 (0.47-62.33) 2.05 (0.09-46.80)
PaO2/FiO2 ≤ 200 (%) 79/164 (48.2) 52/55 (94.5) < 0.001 40.81 (5.49-303.51) 27.16 (2.64-279.70)
APACHE II score, median (IQR) 6 (3-10) 12 (8-16) < 0.001 1.13 (1.09-1.18) 1.07 (0.98-1.18)
Dyspnoea (%) 139/315 (44.1) 58/76 (76.3) < 0.001 4.08 (2.30-7.24) 1.81 (0.47-7.05)
Hemoptysis (%) 33/315 (10.5) 21/75 (28.0) < 0.001 3.32 (1.79-6.18) 1.64 (0.37-7.27)
CNS symptom (%) 29/314 (9.2) 19/76 (25.0) < 0.001 3.27 (1.71-6.24) 2.99 (0.63-14.14)
AST (u/L), median (IQR) 35 (23-65) 96.10 (44.50-159.5) < 0.001 1.007 (1.004-1.011) 1.00 (0.99-1.00)
  1. OR, Odds Ratio; CI, confidence Interval; ORuadj, unadjusted odds ratio; ORadj, Adjusted odds ratio; BMI, body mass index; IQR, interquartile range; APACHE II, acute physiology and chronic health evaluation II
  2. * Data are presented as no./total no., if otherwise stated. Percentages are based on women with complete information in the respective categories
  3. Variables included in univariate model: Age, BMI, Gestational age, comorbidity, pneumonia and symptoms and lab findings on admission associated with mortality
  4. Variables included in multivariate model: BMI, Gestational age, PaO2/FiO2 on admission, APACHE II score, dyspnoea, hemoptysis, CNS symptom, AST
  5. ** Comorbidity included Respiratory diseases (asthma, COPD, active tuberculosis and other bronchial disease), cardiovascular diseases (heart disease, chronic congestive heart failure, valvular disease), diabetes mellitus, cancer or hematological diseases and Immune suppressed