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Table 1 Characteristics of children at the time of enrollment (N=2649)

From: Macrolide resistance determinants among Streptococcus pneumoniae isolates from carriers in Central Greece

Characteristic Year of surveillance P
  2005 2006 2007 2009  
Time-period of enrollment February 28 to June 7 February 2 to April 13 February 26 to May 17 February 24 to May 19  
 PCV7 in the National Immunization Program -- + + +  
 PCV7 reimbursed -- -- + +  
No. of enrolled children 769 494 566 820  
Age, median (range), months 49 (15–76) 46.5 (13–70) 46 (13–73) 48 (14–72)
Male gender 417 (54.2)a 248 (50.2) 297 (52.5) 427 (52.1) 0.529
Antibiotic use in the preceding 3 months 433/764b (56.7) 260/489 (53.2) 284/566 (50.2) 459/818 (56.1) 0.647
Vaccinated with ≥1 dose of PCV7 99 (12.9) 161 (32.6) 397 (70.1) 783 (95.5) <0.001
 Age-appropriately vaccinated 92 (12) 150 (30.4) 351 (62) 668 (81.5) <0.001
Streptococcus pneumoniae carriage      
  per age-group, months      
 13 − 23 12/21 (57.1) 11/22 (50) 18/26 (69.2) 13/18 (72.2) 0.176
 24 – 35 74/121 (61.2) 34/69 (49.3) 50/99 (50.5) 43/100 (43) 0.01
 36 – 47 130/231 (56.3) 78/185 (42.2) 84/183 (45.9) 118/279 (42.3) 0.006
 48 – 59 101/240 (42.1) 70/188 (37.2) 109/208 (52.4) 132/349 (37.8) 0.721
 ≥60 53/156 (34) 13/30 (43.3) 25/50 (50) 28/74 (37.8) 0.273
 Overall 370 (48.1) 206 (41.7) 286 (50.5) 334 (40.7) 0.036
  1. aNumber in parentheses is percent, unless otherwise indicated.
  2. bThe denominator indicates the number of children with available information on recent antibiotic use.