| |
n = 198 (%)
|
n = 12 (%)
| | | |
|
Mean age, years
|
45.8±18.2
|
48.3±12.7
| | | |
|
Sex (male/female)
|
147/51
|
9/3
|
1.0
|
1.041
|
0.27-3.99
|
|
Median (IQR) GCS on presentation
|
15 (14, 15)
|
13.5 (10.3, 15.0)
|
0.39
| | |
|
Underlying diseases
| | | | | |
|
Congenital heart diseases
|
2 (0.1)
|
0
|
1.0
|
0.942
|
0.911-0.975
|
|
Diabetes mellitus
|
42 (21.2)
|
1 (8.3)
|
0.466
|
0.34
|
0.042-2.69
|
|
Alcoholism/liver cirrhosis
|
9 (4.5)
|
0
|
1.0
|
0.94
|
0.91-0.97
|
|
Chronic otitis media
|
20 (10.1)
|
8 (66.6)
|
<0.0001
|
17.8
|
4.9-64.4
|
|
Postneurosurgical state
|
43 (21.7)
|
5 (41.6)
|
0.151
|
2.58
|
0.778-8.52
|
|
Neuroimaging findings at presentation
| | | | | |
|
Multiple/ Solitary
| | | | | |
|
Multiloculated
|
41 (20.7)
|
3 (25)
|
0.718
|
1.276
|
0.331-4.929
|
|
Involved temporal lobe
|
65 (32.8)
|
8 (66.6)
|
0.026
|
4.092
|
1.19-14.1
|
|
Hydrocephalus
|
32 (16.2)
|
3 (25)
|
0.426
|
1.729
|
0.444-6.74
|
|
Post-radiation necrosis
|
0 (0)
|
3 (25)
|
<0.001
|
0.044
|
0.023-0.083
|
|
Clinical features following brain abscess
| | | | | |
|
Fever/chills
|
119 (60.1)
|
10 (83.3)
|
0.135
|
3.319
|
0.708-15.55
|
|
Headache
|
108 (54.5)
|
9 (75)
|
0.234
|
2.5
|
0.657-9.512
|
|
Disturbed consciousness
|
87 (43.9)
|
5 (41.6)
|
0.878
|
0.911
|
0.28-2.97
|
|
Septic shock
|
30 (15.1)
|
1(8.3)
|
1.0
|
0.509
|
0.063-4.09
|
|
Sensory disturbance
|
29 (14.6)
|
0
|
0.379
|
0.934
|
0.898-0.971
|
|
Hemiparesis
|
95 (47.9)
|
4 (33.3)
|
0.324
|
0.542
|
0.158-1.859
|
|
Visual disturbance
|
27 (13.6)
|
1 (8.3)
|
1.0
|
0.576
|
0.071-4.641
|
|
Neck Stiff neck
|
59 (29.8)
|
5 (41.6)
|
0.519
|
1.683
|
0.513-5.517
|
|
Facial palsy
|
12 (6)
|
1 (8.3)
|
0.545
|
1.409
|
0.168-11.842
|
|
Seizure
|
50 (25.2)
|
0
|
0.074
|
0.925
|
0.885-0.967
|
|
Speech disturbance
|
8 (4)
|
0
|
1.0
|
0.941
|
0.909-0.974
|
|
concomitant bacterial meningitis
|
74 (37.4)
|
4 (33.3)
|
1.0
|
0.838
|
0.244-2.879
|
|
Treatment
| | | | | |
|
Combination of Surgical and antimicrobial therapy
|
162 (81.8)
|
10 (83.3)
|
1.0
|
1.11
|
0.23-5.29
|
|
Antimicrobial treatment only
|
36 (18.2)
|
2 (16.6)
| | | |
|
Outcome
| | | | | |
|
Death
|
41 (20.7)
|
2 (16.7)
|
1.0
|
0.766
|
1.61-3.63
|
|
Median (IRQ) hospitalization days
|
44 (28–66.5)
|
35 (25.5- 56.8)
|
0.501
| | |
|
Median (IQR) GOS at discharge
|
4 (2–5)
|
4 (1.3 5.0)
|
0.544
| | |
|
Median (IQR) GOS at a minimum of 18 month follow-up
|
5 (5–5)
|
5 (4.3- 5.0)
|
0.385
| | |
