Skip to main content

Table 1 Clinical comparisons of patients with bacterial brain abscesses without or without NPC

From: Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes

 

Non-NPC patients

NPC patients

p value

OR

95% CI

 

n = 198 (%)

n = 12 (%)

   

Mean age, years

45.8±18.2

48.3±12.7

   

Sex (male/female)

147/51

9/3

1.0

1.041

0.27-3.99

Median (IQR) GCS on presentation

15 (14, 15)

13.5 (10.3, 15.0)

0.39

  

Underlying diseases

     

   Congenital heart diseases

2 (0.1)

0

1.0

0.942

0.911-0.975

   Diabetes mellitus

42 (21.2)

1 (8.3)

0.466

0.34

0.042-2.69

   Alcoholism/liver cirrhosis

9 (4.5)

0

1.0

0.94

0.91-0.97

   Chronic otitis media

20 (10.1)

8 (66.6)

<0.0001

17.8

4.9-64.4

   Postneurosurgical state

43 (21.7)

5 (41.6)

0.151

2.58

0.778-8.52

Neuroimaging findings at presentation

     

Multiple/ Solitary

     

  Multiloculated

41 (20.7)

3 (25)

0.718

1.276

0.331-4.929

  Involved temporal lobe

65 (32.8)

8 (66.6)

0.026

4.092

1.19-14.1

  Hydrocephalus

32 (16.2)

3 (25)

0.426

1.729

0.444-6.74

  Post-radiation necrosis

0 (0)

3 (25)

<0.001

0.044

0.023-0.083

Clinical features following brain abscess

     

  Fever/chills

119 (60.1)

10 (83.3)

0.135

3.319

0.708-15.55

  Headache

108 (54.5)

9 (75)

0.234

2.5

0.657-9.512

  Disturbed consciousness

87 (43.9)

5 (41.6)

0.878

0.911

0.28-2.97

  Septic shock

30 (15.1)

1(8.3)

1.0

0.509

0.063-4.09

  Sensory disturbance

29 (14.6)

0

0.379

0.934

0.898-0.971

  Hemiparesis

95 (47.9)

4 (33.3)

0.324

0.542

0.158-1.859

  Visual disturbance

27 (13.6)

1 (8.3)

1.0

0.576

0.071-4.641

  Neck Stiff neck

59 (29.8)

5 (41.6)

0.519

1.683

0.513-5.517

  Facial palsy

12 (6)

1 (8.3)

0.545

1.409

0.168-11.842

  Seizure

50 (25.2)

0

0.074

0.925

0.885-0.967

  Speech disturbance

8 (4)

0

1.0

0.941

0.909-0.974

  concomitant bacterial meningitis

74 (37.4)

4 (33.3)

1.0

0.838

0.244-2.879

Treatment

     

  Combination of Surgical and antimicrobial therapy

162 (81.8)

10 (83.3)

1.0

1.11

0.23-5.29

  Antimicrobial treatment only

36 (18.2)

2 (16.6)

   

Outcome

     

  Death

41 (20.7)

2 (16.7)

1.0

0.766

1.61-3.63

  Median (IRQ) hospitalization days

44 (28–66.5)

35 (25.5- 56.8)

0.501

  

  Median (IQR) GOS at discharge

4 (2–5)

4 (1.3 5.0)

0.544

  

  Median (IQR) GOS at a minimum of 18 month follow-up

5 (5–5)

5 (4.3- 5.0)

0.385

  
  1. Abbreviations: IVROBA, Intra-ventricular rupture of brain abscess; GOS, Glasgow Outcome Scale; IQR, inter-quartile range; GCS, Glasgow Coma Scale; β, neuro-imaging findings upon presentation.
Back to article page

BMC Infectious Diseases

ISSN: 1471-2334

Contact us