Covariate | Treatment failure (%) | Treatment success (%) | Crude hazard risk (95 CI**) | Adjusted hazard risk (95 CI**) |
---|---|---|---|---|
Weight for Age | ||||
-Below 3rd centile€ | 52(30.2) | 120(69.8) | 2.74(1.09-6.89) | 0.54(0.13-2.25) |
>3rd < 97th centile | 107(55.7) | 85(44.3) | 0.79(0.32-1.92) | 0.41(0.11-1.55) |
Above 97th centile | 6(13.6) | 38(86.4) | 1 | 1 |
Height for Age | ||||
Below 3rd centile | 88(27) | 239(63) | 2.61(1.29-5.29) | 3.25(1.00-10.58) |
>3rd < 97th centile | 66(8.7) | 697(91.3) | 0.67(0.33-1.37) | 1.05(0.33-3.33) |
Above 97th centile | 10(22.2) | 71(77.8) | 1 | 1 |
Weight for Height | ||||
Below 3rd centile | 15(14.3) | 90(85.7) | 1.10(0.61-1.98) | |
>3rd < 97th centile | 41(16.7) | 204(83.3) | 1.33(0.89-1.98) | |
Above 97th centile | 93(13.2) | 614(86.8) | 1 | |
WHO Clinical stage | ||||
Stages 1 or 2 | 58(12.7) | 400(87.3) | 0.84(0.59-1.18) | |
Stage 3 or 4 | 107(14.8) | 617(85.2) | 1 | |
Adherence to HAART | ||||
Optimal | 162(14) | 1006(86) | 0.41(0.15-1.19) | |
Suboptimal | 5(27.3) | 13(72.7) | 1 | |
Initial HAART Regimen | ||||
PI based £ | 10(32.3) | 21(67.7) | 3.03(1.40-6.55) | 1.05(0.33-3.89) |
NNRTI + NRTI | 157(13.6) | 998(86.4) | 1 | 1 |
HAART drug substitution | ||||
Yes | 29(23.6) | 94(76.4) | 2.07(1.31-3.25) | 1.695(1.053-2.728) |
None | 138(13) | 925(87) | 1 | 1 |
HAART Dosing preparation | ||||
Fixed | 9(17.6) | 42(82.4) | 1.18(0.56-2.49) | |
Separate | 109(15.4) | 600(84.6) | 1 | |
CD4 Count at initiation | ||||
(cells/mm3) | ||||
<50 | 19(23.8) | 61(76.2) | 2.39(1.38-4.15) | 2.30(1.28-4.14) |
≥50 | 112(11.5) | 859(88.5) | 1 | 1 |
Chronic Diarrhea after initiation of ART¥ | ||||
Yes | 6(37.5) | 10 (62.5) | 3.76(1.35-1.50) | 3.44 (1.37-8.62) |
None | 161(13.8) | 1009(86.2) | 1 | 1 |