Table 1 Sample characteristics according to the presence of clinical lipodystrophy
Without CL | With CL | P | |
|---|---|---|---|
n (%) | 139 | 206 | |
Gender [n (%)] | |||
Male | 85 (61.2) | 154 (74.8) | 0.007 |
Female | 54 (38.8) | 52 (25.2) | |
Age [years, mean (sd)] | 44.2 (12.1) | 46.9 (10.7) | 0.007 |
Duration of HIV infection [years, median (IQR)] | 6.0 (5.0) | 9.0 (5.0) | <0.001 |
cART [years, median (IQR)] | 4.0 (5.0) | 8.0 (5.0) | <0.001 |
Weight [Kg, mean (sd)] | 73.7 (14.1) | 66.2 (12.4) | <0.001 |
Height [m, mean (sd)] | 1.65 (0.09) | 1.66 (0.09) | 0.368 |
BMI [(kg/m2), median (IQR)] | 26.3 (5.9) | 23.8 (5.1) | <0.001 |
Waist circumference [cm, median (IQR)] | 94.0 (17.0) | 89.0 (14.5) | <0.001 |
Hip circumference [cm, median (IQR)] | 99.0 (11.0) | 91.0 (9.0) | <0.001 |
Thigh circumference [cm, mean (sd)] | 50.0 (5.5) | 46.1 (6.1) | <0.001 |
Arm circumference [cm, mean (sd)] | 28.1 (3.1) | 26.6 (4.1) | <0.001 |
Neck circumference [cm, mean (sd)] | 37.2 (3.7) | 37.1 (4.0) | 0.940 |
CD4 cell count [cells/mm3, median (IQR)] | 446.5 (342.2) | 544.0 (387.0) | 0.008 |
HIV RNA (<50) [n (%)] | 93 (81.6) | 163 (91.1) | 0.017 |
Smoking history [n (%)] | |||
Never | 61 (44.2) | 70 (34.8) | 0.219 |
Current | 55 (39.9) | 93 (46.3) | |
Former | 22 (15.9) | 38 (18.9) | |
HIV risk factor [n (%)] | |||
Injecting drug user | 28 (24.6) | 52 (30.6) | 0.247 |
Homosexual contact | 10 (8.8) | 19 (11.2) | |
Heterosexual contact | 76 (65.8) | 90 (52.9) | |
Others | 1 (0.9) | 9 (5.3) | |
Hepatitis C co-infection [n (%)] | 31 (25.2) | 58 (31.4) | 0.300 |
CDC [n (%)] | |||
A | 62 (54.9) | 94 (53.4) | 0.037 |
B | 4 (3.5) | 0 (0) | |
C | 47 (41.6) | 82 (46.6) | |
ART [n (%)] | |||
IP | 67 (61.5) | 98 (55.4) | 0.310 |
NNRTI | 47 (43.1) | 83 (46.9) | 0.534 |
NRTI | 104 (95.4) | 175 (98.9) | 0.110 |
Hypoglycemic therapy [n (%)] | |||
Oral anti-diabetic drugs | 10.1 % (14) | 14.6 % (30) | 0.132 |
Insulin | 4.3 % (6) | 7.3 % (15) | 0.261 |
Body fat mass by quantitative CT | |||
Total fat [cm2, median (IQR)] | 340.5 (196.6) | 213.6 (175.2) | <0.001 |
Central fat [cm2, median (IQR)] | 110.8 (111.4) | 114.8 (120.5) | 0.800 |
Peripheral fat [cm2, median (IQR)] | 186.2 (172.0) | 78.7 (104.9) | <0.001 |
Central/peripheral fat ratio [cm2, median (IQR)] | 0.51 (0.55) | 1.34 (2.15) | <0.001 |
FMR by DXA [median (IQR)] | 1.06 (0.57) | 1.79 (1.37) | <0.001 |