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Table 1 Baseline characteristics of the patients, overall and in each treatment group

From: Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors

  Total
n.49
Exposure to TDF Exposure to concomitant use of TDF and PI
   A
TDF
n.31 (63%)
B
NO TDF
n.18 (37%)
p C
TDF+PI
n.23 (47%)
D
NO TDF+PI
n.26 (53%)
p
Female n (%) 28 (57%) 18 (58%) 10 (56%) 0.86 12 (52%) 16 (62%) 0.51
Age Mean (SD) 13.6 (± 2.5) 14.0 13.0 0.18 14.1 (± 2.7) 13.2(± 2.3) 0.20
HIV < 50 copies/mL 23 (47%) 12 (39%) 11 (61%) 0.13 9 (39%) 14 (54%) 0.30
CD4% (SD) 27.1 (± 10.2) 24.7 (± 10.4) 31.8 (± 8.3) 0.04 23.6 (± 10.5) 30.7 (± 8.8) 0.02
Ethnicity (Africa) 8 (16%) 3 (10%) 5 (28%) 0.10 2(9%) 6 (23%) 0.17
eGFR at baseline median ml/min per 1.73 m2(IQR) 143.6 (124.5-167.4 143.6 (123.7-165.4) 147.5 (124.5-169.6) 0.48* 135.0 (122.2-156.0) 152.6 (128.0-169.6) 0.14*
Phosphatemia at baseline Median mg/dl (IQR) 4.4 (3.8-5.0) 4.4 (3.8-5.0) 4.7 (3.8-5.2) 0.30* 4.4 (3.9-5.0) 4.5 (3.8-5.1) 0.44*
Years on current regimen mean (SD) 1.11 (1,64) 0,76 (1,30) 1,71 (1,99) 0.06 1 (1,41) 1,21 (1,84) 0.67
ART regimen        
TDF+FTC+LPV/r 10 (20%) 10 (32%) - - 10 (43%)   -
TDF+FTC+ATV/r 11 (22%) 11 (35%) - - 11 (48%)   -
TDF+FTC+Other PI/r 2 (4%) 2 (6%) - - 2 (9%)   -
ABC+3TC+LPV/r 6 (12%) - 6 (33%) - - 6 (23%) -
ABC+3TC+other PI 4 (8%) - 4 (22%) - - 4 (15%) -
3TC+ABC+EFV 7 (14%) - 7 (39%) - - 7 (27%) -
ABC+3TC+AZT 1 (2%) - 1 (6%) - - 1 (4%) -
TDF+ABC+EFV 1 (2%) 1 (3%) - - - 1 (4%) -
TDF+FTC+EFV 7 (14%) 7 (23%) - - - 7 (27%) -
  1. SD Standard Deviation; p value calculated with ANOVA or with Mann Whitney test (*) and was referred to comparison between baseline variable of Group A versus Group B, or Group C versus Group D. TDF Tenofovir Disoproxil Fumarate; FTC= Emtricitabine; LPV/r = Lopinavir/ritonavir; ATV/r Atazanavir/ritonavir; PI/r= Ritonavir boosted Protease Inhibitors; ABC= Abacavir; 3TC= Lamivudine; EFV= Efavirenz; AZT= Zidovudine; OT Other Treatments; r= ritonavir; IQR interquartile range