Table 3 Percentage of subjects (with 95% confidence intervals) reporting solicited systemic symptoms within 7 days after the first and after the second dose of H1N1 vaccine in adults aged 18 to 60 years and in adults >60 years
Symptom | Intensity | Group A Vaccinated on Day 0 and Day 21 | Group B Vaccinated on Day 0 and Day 182 | ||
|---|---|---|---|---|---|
Dose 1% (95% CI) | |||||
18-60 years N = 92 | >60 years N = 90 | 18-60 years N = 70 | >60 years N = 52 | ||
Fatigue | Any | 43.5 | 28.9 | 38.6 | 34.6 |
(33.2-54.2) | (19.8-39.4) | (27.2-51.0) | (22.0-49.1) | ||
Grade 3* | 0.0 | 0.0 | 1.4 | 0.0 | |
(0.0-3.9) | (0.0-4.0) | (0.0-7.7) | (0.0-6.8) | ||
Headache | Any | 37.0 | 22.2 | 31.4 | 17.3 |
(27.1-47.7) | (14.1-32.2) | (20.9-43.6) | (8.2-30.3) | ||
Grade 3* | 0.0 | 1.1 | 1.4 | 0.0 | |
(0.0-3.9) | (0.0-6.0) | (0.0-7.7) | (0.0-6.8) | ||
Joint pain at other location | Any | 22.8 | 21.1 | 14.3 | 15.4 |
(14.7-32.8) | (13.2-31.0) | (7.1-24.7) | (6.9-28.1) | ||
Grade 3* | 0.0 | 0.0 | 0.0 | 0.0 | |
(0.0-3.9) | (0.0-4.0) | (0.0-5.1) | (0.0-6.8) | ||
Muscle aches | Any | 46.7 | 28.9 | 32.9 | 28.8 |
(36.3-57.4) | (19.8-39.4) | (22.1-45.1) | (17.1-43.1) | ||
Grade 3* | 0.0 | 0.0 | 0.0 | 1.9 | |
(0.0-3.9) | (0.0-4.0) | (0.0-5.1) | (0.0-10.3) | ||
Shivering | Any | 18.5 | 13.3 | 20.0 | 11.5 |
(11.1-27.9) | (7.1-22.1) | (11.4-31.3) | (4.4-23.4) | ||
Grade 3* | 0.0 | 1.1 | 0.0 | 0.0 | |
(0.0-3.9) | (0.0-6.0) | (0.0-5.1) | (0.0-6.8) | ||
Sweating | Any | 13.0 | 11.1 | 10.0 | 13.5 |
(6.9-21.7) | (5.5-19.5) | (4.1-19.5) | (5.6-25.8) | ||
Grade 3* | 1.1 | 0.0 | 0.0 | 0.0 | |
(0.0-5.9) | (0.0-4.0) | (0.0-5.1) | (0.0-6.8) | ||
Fever (Axillary temp) | Any | 1.1 | 1.1 | 2.9 | 1.9 |
(0.0-5.9) | (0.0-6.0) | (0.3-9.9) | (0.0-10.3) | ||
≥39.0 to ≤40°C | 0.0 | 0.0 | 0.0 | 0.0 | |
(0.0-3.9) | (0.0-4.0) | (0.0-5.1) | (0.0-6.8) | ||
Dose 2% (95% CI) | |||||
18-60 years N = 91 | >60 years N = 85 | 18-60 years N = 60 | >60 years N = 45 | ||
Fatigue | Any | 53.8 | 31.8 | 51.7 | 29.5 |
(43.1-64.4) | (22.1-42.8) | (38.4-64.8) | (16.8-45.2) | ||
Grade 3* | 3.3 | 1.2 | 3.3 | 0.0 | |
(0.7-9.3) | (0.0-6.4) | (0.4-11.5) | (0.0-8.0) | ||
Headache | Any | 45.1 | 22.4 | 35.0 | 25.0 |
(34.6-55.8) | (14.0-32.7) | (23.1-48.4) | (13.2-40.3) | ||
Grade 3* | 1.1 | 1.2 | 5.0 | 0.0 | |
(0.0-6.0) | (0.0-6.4) | (1.0-13.9) | (0.0-8.0) | ||
Joint pain at other location | Any | 19.8 | 24.7 | 26.7 | 27.3 |
(12.2-29.4) | (16.0-35.3) | (16.1-39.7) | (15.0-42.8) | ||
Grade 3* | 0.0 | 0.0 | 0.0 | 0.0 | |
(0.0-4.0) | (0.0-4.2) | (0.0-6.0) | (0.0-8.0) | ||
Muscle aches | Any | 42.9 | 29.4 | 51.7 | 34.1 |
(32.5-53.7) | (20.0-40.3) | (38.4-64.8) | (20.5-49.9) | ||
Grade 3* | 0.0 | 0.0 | 1.7 | 0.0 | |
(0.0-4.0) | (0.0-4.2) | (0.0-8.9) | (0.0-8.0) | ||
Shivering | Any | 28.6 | 15.3 | 18.3 | 15.9 |
(19.6-39.0) | (8.4-24.7) | (9.5-30.4) | (6.6-30.1) | ||
Grade 3* | 1.1 | 1.2 | 0.0 | 0.0 | |
(0.0-6.0) | (0.0-6.4) | (0.0-6.0) | (0.0-8.0) | ||
Sweating | Any | 20.9 | 16.5 | 13.3 | 9.1 |
(13.1-30.7) | (9.3-26.1) | (5.9-24.6) | (2.5-21.7) | ||
Grade 3* | 1.1 | 0.0 | 0.0 | 0.0 | |
(0.0-6.0) | (0.0-4.2) | (0.0-6.0) | (0.0-8.0) | ||
Fever (Axillary temp) | Any | 6.6 | 5.9 | 1.7 | 0.0 |
(2.5-13.8) | (1.9-13.2) | (0.0-8.9) | (0.0-8.0) | ||
≥39.0 to ≤40°C | 0.0 | 2.4 | 0.0 | 0.0 | |
(0.0-4.0) | (0.3-8.2) | (0.0-6.0) | (0.0-8.0) | ||