Skip to main content

Table 3 Percentage of subjects (with 95% confidence intervals) reporting solicited systemic symptoms within 7 days after the first and after the second dose of H1N1 vaccine in adults aged 18 to 60 years and in adults >60 years

From: Flexibility of interval between vaccinations with AS03A-adjuvanted influenza A (H1N1) 2009 vaccine in adults aged 18–60 and >60 years: a randomized trial

Symptom Intensity Group A Vaccinated on Day 0 and Day 21 Group B Vaccinated on Day 0 and Day 182
Dose 1% (95% CI)
18-60 years N = 92 >60 years N = 90 18-60 years N = 70 >60 years N = 52
Fatigue Any 43.5 28.9 38.6 34.6
(33.2-54.2) (19.8-39.4) (27.2-51.0) (22.0-49.1)
Grade 3* 0.0 0.0 1.4 0.0
(0.0-3.9) (0.0-4.0) (0.0-7.7) (0.0-6.8)
Headache Any 37.0 22.2 31.4 17.3
(27.1-47.7) (14.1-32.2) (20.9-43.6) (8.2-30.3)
Grade 3* 0.0 1.1 1.4 0.0
(0.0-3.9) (0.0-6.0) (0.0-7.7) (0.0-6.8)
Joint pain at other location Any 22.8 21.1 14.3 15.4
(14.7-32.8) (13.2-31.0) (7.1-24.7) (6.9-28.1)
Grade 3* 0.0 0.0 0.0 0.0
(0.0-3.9) (0.0-4.0) (0.0-5.1) (0.0-6.8)
Muscle aches Any 46.7 28.9 32.9 28.8
(36.3-57.4) (19.8-39.4) (22.1-45.1) (17.1-43.1)
Grade 3* 0.0 0.0 0.0 1.9
(0.0-3.9) (0.0-4.0) (0.0-5.1) (0.0-10.3)
Shivering Any 18.5 13.3 20.0 11.5
(11.1-27.9) (7.1-22.1) (11.4-31.3) (4.4-23.4)
Grade 3* 0.0 1.1 0.0 0.0
(0.0-3.9) (0.0-6.0) (0.0-5.1) (0.0-6.8)
Sweating Any 13.0 11.1 10.0 13.5
(6.9-21.7) (5.5-19.5) (4.1-19.5) (5.6-25.8)
Grade 3* 1.1 0.0 0.0 0.0
(0.0-5.9) (0.0-4.0) (0.0-5.1) (0.0-6.8)
Fever (Axillary temp) Any 1.1 1.1 2.9 1.9
(0.0-5.9) (0.0-6.0) (0.3-9.9) (0.0-10.3)
≥39.0 to ≤40°C 0.0 0.0 0.0 0.0
(0.0-3.9) (0.0-4.0) (0.0-5.1) (0.0-6.8)
   Dose 2% (95% CI)
18-60 years N = 91 >60 years N = 85 18-60 years N = 60 >60 years N = 45
Fatigue Any 53.8 31.8 51.7 29.5
(43.1-64.4) (22.1-42.8) (38.4-64.8) (16.8-45.2)
Grade 3* 3.3 1.2 3.3 0.0
(0.7-9.3) (0.0-6.4) (0.4-11.5) (0.0-8.0)
Headache Any 45.1 22.4 35.0 25.0
(34.6-55.8) (14.0-32.7) (23.1-48.4) (13.2-40.3)
Grade 3* 1.1 1.2 5.0 0.0
(0.0-6.0) (0.0-6.4) (1.0-13.9) (0.0-8.0)
Joint pain at other location Any 19.8 24.7 26.7 27.3
(12.2-29.4) (16.0-35.3) (16.1-39.7) (15.0-42.8)
Grade 3* 0.0 0.0 0.0 0.0
(0.0-4.0) (0.0-4.2) (0.0-6.0) (0.0-8.0)
Muscle aches Any 42.9 29.4 51.7 34.1
(32.5-53.7) (20.0-40.3) (38.4-64.8) (20.5-49.9)
Grade 3* 0.0 0.0 1.7 0.0
(0.0-4.0) (0.0-4.2) (0.0-8.9) (0.0-8.0)
Shivering Any 28.6 15.3 18.3 15.9
(19.6-39.0) (8.4-24.7) (9.5-30.4) (6.6-30.1)
Grade 3* 1.1 1.2 0.0 0.0
(0.0-6.0) (0.0-6.4) (0.0-6.0) (0.0-8.0)
Sweating Any 20.9 16.5 13.3 9.1
(13.1-30.7) (9.3-26.1) (5.9-24.6) (2.5-21.7)
Grade 3* 1.1 0.0 0.0 0.0
(0.0-6.0) (0.0-4.2) (0.0-6.0) (0.0-8.0)
Fever (Axillary temp) Any 6.6 5.9 1.7 0.0
(2.5-13.8) (1.9-13.2) (0.0-8.9) (0.0-8.0)
≥39.0 to ≤40°C 0.0 2.4 0.0 0.0
(0.0-4.0) (0.3-8.2) (0.0-6.0) (0.0-8.0)
  1. *Grade 3 events were defined as events that prevent normal everyday activities (inability to attend/do work), or that require intervention of a physician/healthcare provider.