Children will be included if: | Children will be excluded if: |
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Aged before their fifth birthday. | Aged 5 years and above. |
Presenting at a participating NHS primary care site. | Parents are unable or unwilling to assist with study. |
Presenting with an acute (≤28 days) illness as the main reason for the parent to have requested an appointment. | Illness longer than 28 days duration. |
 | Presenting with trauma as a predominant concern. |
Presenting with at least one ’constitutional’ symptom or sign identified by NICE [9] as a potential marker for UTI – that is, fever, vomiting, lethargy/malaise, irritability, poor feeding and failure to thrive and/or at least one urinary symptom identified by NICE [9] as a potential marker of UTI – that is, abdominal pain, jaundice (children <3 months only), haematuria, offensive urine, cloudy urine, loin tenderness, frequency, apparent pain on passing urine and changes to continence. | No urinary or constitutional symptoms as defined by NICE [9] and listed in the left hand column. |
 | Known neurogenic (e.g. spina bifida) or surgically reconstructed bladder or urinary permanent or intermittent catheterisation (for whom different bacterial concentration cut points are used). |
 | Taking any antibiotics in the last 7 days. |
 | Taking immunosuppressant medication (e.g. anti-rejection drugs, oral or intramuscular steroids or chemotherapy). |
 | Already recruited into the DUTY study. |
 | Involved in current research or have recently (within 28 days) been involved in any research prior to recruitment. |
 | There will be no recruitment to the study after the last NHS laboratory transport of the day has departed from that primary care site on Fridays. |
 | For recruitment at A&E settings only: children will not be eligible if their presentation at A&E is a direct result of GP referral. |