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Table 2 CD4 count six months after ART initiation and CD4 changes estimated by adjusted linear mixed model, relative to the viral load six and 12 months after starting ART (HIV-RNA threshold 10,000 copies), ART-LINC of IeDEA

From: Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings

Variables Mean CD4 cell count at M6 (cells/μL) 95% CI p value
Viral load at M6    <0.0001
 <500 289* 277;301  
 [500–10,000[ (vs <500) −3 −26;+20  
 ≥10,000 (vs <500) −82 −106;-58  
Gender    0.0005
 Male vs female −18 −29;+8  
Age at starting ART (years)    0.0451
 [16-30[ vs. ≥40 +13 −1;+27  
 [30-35[ vs. ≥40 −3 −16;+10  
 [35-40[ vs. ≥40 −7 −21;+7  
Year of starting ART    0.0111
 Prior to 2004 vs. up to 2003 +14 +3;+25  
Stage at starting ART    <0.0001
 III vs. A,B/I,II −50 −62;-38  
 AIDS/IV vs. A,B/I,II −46 −58;-33  
 Unknown vs. A,B/I,II −5 −24;+14  
  Mean CD4 cell count change from M6 to M18 (cells/μL)   
Viral load at M6 and M12 *    <0.0001
 Viral load <500 at M6 and <500 at M12 +90 +71;+108  
 Viral load <500 at M6 and [500–10,000[ at M12 +49 +7;+91  
 Viral load <500 at M6 and ≥10,000 at M12 +1 −47;+49  
 Viral load = [500–10,000[ at M6 and <500 at M12 +64 +37;+90  
 Viral load = [500–10,000[ at M6 and = [500–10,000[ at M12 +23 −22;+68  
 Viral load = [500–10,000[ at M6 and ≥10,000 at M12 −25 −76;+26  
 Viral load ≥10,000 at M6 and <500 at M12 +87 +59;+115  
 Viral load ≥10,000 at M6 and = [500–10,000[ at M12 +46 0;+93  
 Viral load ≥10,000 at M6 and ≥10,000 at M12 −1 −51;+48  
  1. * For the reference group: up to 39 year old women, starting ART up to 2003 at clinical stage WHO I,II or CDC A,B with a viral load <500 copies/mL six months after ART initiation.
  2. ART: Antiretroviral treatment.
  3. 95% CI: 95% confidence interval.