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Table 3 Lung cytokine and chemokine levels and pathology scores in splenectomized WT and TLR2x4KO mice 24 hours after intranasal infection with serotype 2S. pneumoniae

From: The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen

  WT TLR2x4 KO
TNF-α 1260 ± 209 1399 ± 227
IL-1β 226 ± 120 207 ± 62
MIP-2 1731 ± 290 2161 ± 542
KC 3597 ± 1536 6058 ± 3416
TLIS 7,2 ± 2,3 7,3 ± 0,8
Ly-6 G 3,3 ± 0,4 3,6 ± 1,0
  1. Whole lung homogenates were obtained at 24 hours after intranasal infection with 4*105 CFU of S. pneumoniae. Data are means ± SEM (N = 7 per group). TNF-α, IL-1β, MIP-2 and KC values are in pg/ml. TLIS = total lung inflammation score in arbitrary units, as described in the Methods section.
  2. Ly-6 G score = percentage of lung surface that is Ly-6 G positive, see Methods section.