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Table 1 Lung cytokine and chemokine levels in splenectomized WT and TLR2KO mice, 6 and 24 h after infection with serotype 2 S. pneumoniae

From: The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen

 

6 h

24 h

 

WT

TLR2KO

WT

TLR2KO

TNF-α

1581 ± 268

1376 ± 190

1290 ± 49

1515 ± 249

IL-1β

173,5 ± 37

249,9 ± 91

132,9 ± 26

186,7 ± 35

MIP-2

2110 ± 333

4172 ± 919 *

951,6 ± 69

798,8 ± 53

KC

1244 ± 254

2680 ± 1825

1292 ± 241

1548 ± 263

  1. Whole lung homogenates were obtained at 6 and 24 hours after intranasal infection with 6*105 CFU of S. pneumoniae serotype 2 (D39). Data are means ± SEM (N = 6–7 per group).
  2. * indicates p < 0.05 versus WT mice. TNF-α, IL-1β, MIP-2 and KC values are in pg/ml.
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BMC Infectious Diseases

ISSN: 1471-2334

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