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Table 1 Lung cytokine and chemokine levels in splenectomized WT and TLR2KO mice, 6 and 24 h after infection with serotype 2S. pneumoniae

From: The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen

  6 h 24 h
  WT TLR2KO WT TLR2KO
TNF-α 1581 ± 268 1376 ± 190 1290 ± 49 1515 ± 249
IL-1β 173,5 ± 37 249,9 ± 91 132,9 ± 26 186,7 ± 35
MIP-2 2110 ± 333 4172 ± 919 * 951,6 ± 69 798,8 ± 53
KC 1244 ± 254 2680 ± 1825 1292 ± 241 1548 ± 263
  1. Whole lung homogenates were obtained at 6 and 24 hours after intranasal infection with 6*105 CFU of S. pneumoniae serotype 2 (D39). Data are means ± SEM (N = 6–7 per group).
  2. * indicates p < 0.05 versus WT mice. TNF-α, IL-1β, MIP-2 and KC values are in pg/ml.