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Table 2 Immunohistochemical analysis of control and EL brain using anti-coxsackievirus antibody

From: Evidence for an enterovirus as the cause of encephalitis lethargica

Dilution 1:3,000 1:6,000 1:10,000 1:20,000 1:40,000 0 antibody
Neutralizing dose/ml 6.8 3.4 2 1 0.5 0
Controls, UK cases
06/112 1+   2+ 2+ 0  
06/110 2+ 0     0
06/126/7 1+      
05/152-9 1+   0    
05/25- 1+      0
05/47-11 0      
NP86/07-4 0      
05/137/5 1+      
05/66-28 0      
05-01-8 0      
Controls, USA
865183-M 1+ 1+     
8889C 2+ 0     
8854127-13 0      
883599-11 2+ 2+ 2+ 2+   
1311056-17 1+      
EL, USA Cases
21225A   3+ 2+ 2+   0
21225B   2+ 3.5+ 2+   
19940C 4+ 0.2+ 0    0
19940B   2.5+ 4+ 3+ 0 0
91558 3+ 2.5+ 1+    1+
28065B 0 1+     0
28065D 3.5+ 2.5+, 3+ 3+, 3+ 2+, 3+   0
28065C 0.5+ 3+, 3+     
28065A 3+ 2+ 0    
  1. Immunohistochemical analysis using anti-coxsackievirus B horse polyclonal antibody on brain from control and archival EL cases. The same expressions for quantitation are used as in Table 1. Case numbers followed by letters indicate different blocks from the same case. When tests were repeated, the two results are indicated in the same box.