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Table 2 Immunohistochemical analysis of control and EL brain using anti-coxsackievirus antibody

From: Evidence for an enterovirus as the cause of encephalitis lethargica

Dilution

1:3,000

1:6,000

1:10,000

1:20,000

1:40,000

0 antibody

Neutralizing dose/ml

6.8

3.4

2

1

0.5

0

Controls, UK cases

06/112

1+

 

2+

2+

0

 

06/110

2+

0

   

0

06/126/7

1+

     

05/152-9

1+

 

0

   

05/25-

1+

    

0

05/47-11

0

     

NP86/07-4

0

     

05/137/5

1+

     

05/66-28

0

     

05-01-8

0

     

Controls, USA

865183-M

1+

1+

    

8889C

2+

0

    

8854127-13

0

     

883599-11

2+

2+

2+

2+

  

1311056-17

1+

     

EL, USA Cases

21225A

 

3+

2+

2+

 

0

21225B

 

2+

3.5+

2+

  

19940C

4+

0.2+

0

  

0

19940B

 

2.5+

4+

3+

0

0

91558

3+

2.5+

1+

  

1+

28065B

0

1+

   

0

28065D

3.5+

2.5+, 3+

3+, 3+

2+, 3+

 

0

28065C

0.5+

3+, 3+

    

28065A

3+

2+

0

   
  1. Immunohistochemical analysis using anti-coxsackievirus B horse polyclonal antibody on brain from control and archival EL cases. The same expressions for quantitation are used as in Table 1. Case numbers followed by letters indicate different blocks from the same case. When tests were repeated, the two results are indicated in the same box.