Total lymphocyte count as a surrogate marker for CD4 count in resource-limited settings

BMC Infectious Diseases

Table 2 Sensitivity, Specificity, Positive and Negative predictive values of Total lymphocyte count cut-off for various CD4 groups

	TLC cut-off (cells/mm3)	Sensitivity (%)	95% CI	Specificity (%)	95% CI	PPV (%)	NPV (%)
	1000	72.22	46.52 to 90.31	94.44	72.71 to 99.86	100	91.7
CD4 count <200	1200	72.22	46.52 to 90.31	100	81.47 to 100.0	100	95.7
(cells/mm ³ )	1400	66.67	40.99 to 86.66	100	81.47 to 100.0	77.8	94.1
	1600	55.56	30.76 to 78.47	100	81.47 to 100.0	65.6	91.7
	1000	100	88.4 to 100	66.67	9.4 to 99.2	96.8	100
CD4 count 200–499	1200	100	88.4 to 101	67.67	9.4 to 99.3	96.7	66.7
(cells/mm ³ )	1500	96.67	82.8 to 99.9	100	29.2 to 100	100	75.0
	1600	93.33	77.9 to 99.2	100	29.2 to 101	100	60.0
	1700	95.45	77.2 to 99.9	63.64	30.8 to 89.1	84.0	87.5
CD4 count ≥500	1750	96.45	77.2 to 99.10	72.73	39.0 to 94.0	87.5	88.9
(cells/mm ³ )	1800	97.45	77.2 to 99.11	90.91	58.7 to 99.8	95.5	90.9
	1900	98.45	77.2 to 99.12	100	71.5 to 100	100	91.7

TLC-Total lymphocyte count; PPV-Predictive positive value; NPV-Negative predictive value; 95% CI- 95% Confidence interval.

ISSN: 1471-2334